Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small elevations in intracellular calcium concentration. The aim of this study was to investigate the role of DOC2B in calcium-triggered exocytosis. Using biochemical and biophysical measurements, we demonstrate that the C2A domain of DOC2B inte...

purpose: to evaluate the effects of diurnal fasting during ramadan on intraocular pressure (iop) in healthy subjects. methods: the study was conducted on healthy male volunteer less than 40 years of age without ocular or systemic diseases who were on religious fasting during ramadan, 2004. intraocular pressure were measured at 9 am and 1, 5, and 7 pm in 2nd and 4th weeks of ramadan and also one...

Hyperglycemic conditions of diabetes accelerate protein modifications by glucose leading to the accumulation of advanced glycation end-products (AGEs). We have investigated the conversion of protein-Amadori intermediate to protein-AGE and the mechanism of its inhibition by pyridoxamine (PM), a potent AGE inhibitor that has been shown to prevent diabetic complications in animal models. During in...

BACKGROUND Chronic particulate matter (PM) exposure is correlated to various health effects, even at low amounts. WHO has defined PM concentration limits as daily and annual mean values which were made legally binding in the European Union. While many studies have focused on PM concentrations in special environments, little is known about the average PM- exposure for both employees and passenge...

The contrasting age-related trends on laboratory and naturalistic prospective memory (PM) studies were investigated with the same participants. In the first two experiments, 380 participants in three age groups (20s, 60s, and 80+) were given a naturalistic PM task of logging the time at four set times for one week. There were six between-subjects regimens that varied the complexity of the time ...

The development of prospective memory (PM) in 3-, 4-, and 5-year-old children (N=123) was assessed in two experiments using several naturalistic game-like tasks that varied in the explicitness of the cues for retrieval that they provided. The goals of the study were to evaluate age differences in PM (a) with the effects of retrospective memory (RM) factored out and (b) as a function of increasi...

The current study examined the role of executive functioning (EF) in children’s prospective memory (PM) by assessing the effect of delay and number of intentions to-be-remembered on PM, as well as relations between PM and EF. Ninety-six 4-, 5-, and 6-year-olds completed a PM task and two executive function tasks. The PM task required children to interrupt an ongoing card game to perform one act...

Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a key enzyme exclusively using free cholesterols as the substrates in cell and is involved in the cellular cholesterol homeostasis. In this study, we used human neuroblastoma cell line SK-N-SH as a model and first observed that inhibiting ACAT1 can decrease the amyloid precursor protein (APP)-α-processing. Meanwhile, the transfection experiments...

Power management is an important issue in the design of Energy Harvesting Wireless Sensor Networks (EHWSNs). In this kind of networks, each Energy Harvesting Node (EH-node) must dynamically adapt its performance in order to avoid power failures while maintaining a good quality of service. The power management policy is implemented on each node by a Power Manager (PM). In this demonstration, the...

Emissions from traffic impose negative effects on human health, and recent evidence indicates that particulate matters (PM) are the detrimental air pollutant that causes most life years lost. To improve the efficiency of resource allocation, various mitigation measures have been proposed for reducing these emissions. However, whether or not the policy instruments are welfare improving, and if y...