نتایج جستجو برای: aggressive fibromatosis
تعداد نتایج: 59062 فیلتر نتایج به سال:
10518 Background: We present updated results from a previously reported phase II trial assessing clinical efficacy of imatinib in progressive or recurrent aggressive fibromatosis (Fayette et al. ASCO 2007) Methods: Patients with aggressive fibromatosis not amenable to radiotherapy or non-mutilating surgery were eligible and received imatinib 400mg daily (increased to 800mg daily in case of prog...
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) regulate the degradation of extracellular matrix components and play important roles in the progression of select neoplastic processes. The locally invasive soft tissue tumor, aggressive fibromatosis (also called desmoid tumor), is caused by mutations resulting in beta-catenin-mediated T-cell factor (tcf)-dependent transcrip...
abstract desmoid tumors (dts) are benign tumors which are not seen very often, and most of the radiologists and clinicians do not know the characteristics of them very well. correct and early diagnosis of dts is important for decreasing mortality and morbidity. computed tomography enterography (cte) is a new modality for small bowel imaging which combines the improved spatial and temporal resol...
Introduction: Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue lesion, composed of a monoclonal proliferation of benignappearing spindle (fibroblast like) cells. A subset of lesions contain a somatic mutation in the adenomatous polyposis coli (APC) gene (1). Familial Adenomatosis Polyposis (FAP) is an inherited pre-neoplastic condition that predisposes to colonic neopla...
PURPOSE To explore the molecular bases of potential new pharmacologic targets in aggressive fibromatosis (desmoid tumor). EXPERIMENTAL DESIGN Tumor specimens from 14 patients surgically treated for aggressive fibromatosis (6 familial adenomatous polyposis and 8 sporadic cases), analyzed for adenomatous polyposis coli (APC) and CTNNB1 (beta-catenin) mutations, were further investigated for bet...
Desmoid tumors, also known as aggressive fibromatosis, are tumors of intermediate dignity, which grow slowly but are locally aggressive. These tumors do not metastasize but can be potentially life threatening when infiltrating vital structures. The therapy strategy consists of surgery, radiation and systemic therapy with non-steroidal anti-inflammatory drugs, antiestrogen compounds and cytotoxi...
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