discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

BACKGROUND Proliferative potential of testicular tumor was assessed by immunohistochemistry using anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody and silver staining of argyrophilic nucleolar organizer region (AgNOR), and the results were compared with clinical course. METHODS Fourty-five patients with testicular tumor and 10 normal testicles were investigated. All specimen...

PURPOSE To evaluate the mutual inter-relationship of mitotic indices, argyrophilic nuclear organizer regions (AgNOR) count, Ki-67 and B-cell lymphoma 2 protein (bcl-2) in papillary urothelial bladder cancer (pUBC), and their correlation with grade and stage. To establish the cut-off values of these markers to detect high grade and muscle invasive bladder cancer. MATERIALS AND METHODS Fifty-fo...

The relation between estrogen receptors (ER) and argyrophilic nucleolar organizer regions (AgNORs) in situ within human breast cancer cells was analyzed. For AgNOR measurements in 49 invasive breast carcinomas, a new reproducible staining method for dual demonstration of ER and AgNORs was applied. Quantitative AgNOR variables were determined in ER-positive and ER-negative tumor cells by digital...

Objective: To evaluate the correlation of argyrophilic nucleolar regions(AgNORs) and malignancy in benign and malignant effusions. Design: The study group consisted of pleural and peritoneal effusion samples obtained from patients suffering from various benign or malignant diseases. The cytological smears were studied by conventional haematoxylin & eosin(H&E) and silver staining for AgNORs. Set...

AIMS To see whether a correlation exists between clinicopathological parameters, argyrophilic nucleolar organiser regions (AgNORs), and nucleolar counts in the nuclei of tumour cells in patients with transitional cell bladder carcinoma. METHODS Paraffin wax embedded sections from a total of 62 cases of primary transitional cell bladder carcinoma were stained with the silver colloid method. Th...

Early detection of oral squamous cell carcinoma (OSCC) and potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half patients with cancer had advanced disease at the time diagnosis, indicating a lack early risk assessment biomarkers. The development new protein biomarkers will help in diagnosis treatment.The argyrophilic nucle...