The Ca(2+)-dependent slow afterhyperpolarization (AHP) is an important determinant of neuronal excitability. Although it is established that modest changes in extracellular pH (pH(o)) modulate the slow AHP, the relative contributions of changes in the priming Ca(2+) signal and intracellular pH (pH(i)) to this effect remain poorly defined. To gain a better understanding of the modulation of the ...

Kumar, Ashok and Thomas C. Foster. 17 -Estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons. J Neurophysiol 88: 621–626, 2002; 10.1152/jn.00065.2002. Disruption of Ca homeostasis is hypothesized to mediate several electrophysiological markers of brain aging. Recent evidence indicates that estradiol can rapidly alter Ca -dependent processes in neurons through nongenomic mechan...

OBJECTIVES To determine the most common ocular causes and types of abnormal head position (AHP) and describe their clinical features. MATERIALS AND METHODS Patients with AHP who had been followed in the strabismus unit were retrospectively reviewed. Demographic features and orthoptic characteristics were recorded. RESULTS A total of 163 patients including 61 women (37.4%) and 102 men (62.6%...

Pyramidal neurons in the piriform cortex from olfactory-discrimination trained rats show enhanced intrinsic neuronal excitability that lasts for several days after learning. Such enhanced intrinsic excitability is mediated by long-term reduction in the post-burst after-hyperpolarization (AHP) which is generated by repetitive spike firing. AHP reduction is due to decreased conductance of a calci...

Selection of qualified persons suitable for different organization functions is a key success factor for an organization. The complexity and importance of the problem call for analytical methods rather than intuitive decisions. The personnel selection problem requires the application of multi-criteria decision making (MCDM) methods for robust recruitment. This paper has to objectives; first to ...

Activation of group I metabotropic glutamate receptors (mGluRs) leads to a concerted modulation of spike afterpotentials in guinea pig hippocampal neurons including a suppression of both medium and slow afterhyperpolarizations (AHPs). Suppression of AHPs may be long-lasting, in that it persists after washout of the agonist. Here, we show that persistent AHP suppression differs from short-term, ...

CA1 pyramidal neurons from animals that have acquired a hippocampus-dependent task show a reduced slow post-burst afterhyperpolarization (slow AHP). To understand the functional significance of this change, we examined and characterized the slow AHP activated by different patterns of synaptic stimuli and its impact on postsynaptic signal integration. Whole cell current-clamp recordings were per...

BACKGROUND Health-promoting lifestyle choices of adolescents are closely related to current and subsequent health status. However, parsimonious yet reliable and valid screening tools are scarce. The original 40-item adolescent health promotion (AHP) scale was developed by our research team and has been applied to measure adolescent health-promoting behaviors worldwide. The aim of our study was ...