introduction: non-alcoholic fatty liver is one of the most prevalent digestive diseases in the world and its prevalence is increasing rapidly. the objective of this study was to compare the treatment effect of pioglitazone and metformin on fatty liver. materials and methods: this double blinded clinical trial study was performed in 2012 among patients referring to gastrointestinal clinics in th...

AIM The aim of this study was to review cases of non-alcoholic fatty liver disease cases and to determine the prevalence of non-alcoholic fatty liver disease as a cause of elevated alanine aminotransferase in healthy blood donors in the Permian area and also assess risk factors of NAFLD such as BMI and correlation with metabolic syndrome in these subjects. BACKGROUND Non-alcoholic fatty liver...

Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes. To investigate the biological outcome and therapeutic potential of hepatic fatty acid uptake inhibition, we utilized an adeno-associated virus-mediated RNA interference technique to knock down the expression of hepatic fatty acid transport protein 5 in vivo prior to or after establishing non-alc...

Non-alcoholic fatty liver disease describes a range of conditions caused by a build-up of fat within liver cells. It is very common and in many cases is linked to being obese or overweight. Most people with non-alcoholic fatty liver disease do not develop serious liver problems. In some people, the build-up of fat in the liver can lead to serious liver disease. However, all people with non-alco...

Non-alcoholic fatty liver disease describes a range of conditions caused by a build-up of fat within liver cells. It is very common and in many cases is linked to being obese or overweight. Most people with non-alcoholic fatty liver disease do not develop serious liver problems. In some people, the build-up of fat in the liver can lead to serious liver disease. However, all people with non-alco...

Background/aims Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Some risk factors are known to influence the development of non-alcoholic fatty liver disease, but the effect of tobacco smoking on the progression of non-alcoholic fatty liver disease is controversial. The main goal of this systematic review and meta-analysis is to investigate the association be...

There are three phases of alcoholic liver disease: fatty liver, which is usually reversible with abstinence; alcoholic hepatitis, or liver inflammation; and cirrhosis, or scarring of the liver. Patients frequently have more than one type of liver disease, such as coexisting fatty liver and alcoholic hepatitis or alcoholic hepatitis together with cirrhosis. Patients with both cirrhosis and alcoh...

Compared with controls, patients with alcoholic fatty liver showed a significant increase of gamma-glutamyltransferase activity both in the liver and serum, whereas alkaline phosphatase activity was raised only in the liver but not in the serum. The activities of other enzymes such as aspartate aminotransferase, alanine aminotransferase and glutamate dehydrogenase remained virtually unchanged i...

introduction worldwide, chronic liver disease is a major cause of morbidity and mortality. causes of elevated serum alanine aminotransferase (alt) levels vary depending on the population under study. the aim of this study is to evaluate the frequency and causes of persistently elevated alt levels in patients of the gastroenterology (gi) clinics in ghaem and emam reza hospitals in mashhad, iran....

background :timely diagnosis of liver cirrhosis is vital for preventing further liver damage and giving the patient the chance of transplantation. although biopsy of the liver is the gold standard for cirrhosis assessment, it has some risks and limitations and this has led to the development of new noninvasive methods to determine the stage and prognosis of the patients. we aimed to design an a...