TANNER MCGINN, BS RESEARCH ASSISTANT RUBIN INSTITUTE FOR ADVANCED ORTHOPEDICS CENTER FOR JOINT PRESERVATION AND REPLACEMENT SINAI HOSPITAL OF BALTIMORE BALTIMORE, MARYLAND MORAD CHUGHTAI, MD RESEARCH FELLOW DEPARTMENT OF ORTHOPAEDIC SURGERY CLEVELAND CLINIC CLEVELAND, OHIO ANIL BHAVE, PT PHYSICAL THERAPIST RUBIN INSTITUTE FOR ADVANCED ORTHOPEDICS CENTER FOR JOINT PRESERVATION AND REPLACEMENT SI...

It isn't always easy to change leadership hats or to alter the way you assess a business problem. Under pressure, most executives fall back on the management style or approach that worked in the last crisis they faced. But old approaches rarely work in new and demanding situations. Just ask Leonard Schaeffer, chairman and CEO of WellPoint Health Networks, one of the country's largest and most s...

INTRODUCTION Acute kidney injury (AKI) and acute lung injury (ALI) are serious complications of sepsis. AKI is often viewed as a late complication of sepsis. Notably, the onset of AKI relative to ALI is unclear as routine measures of kidney function (BUN and creatinine) are insensitive and increase late. In this study, we hypothesized that AKI and ALI would occur simultaneously due to a shared ...

BACKGROUND While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation. Therefore, we hypothesized that mechanical ventilation and concomitant stretch-exposure of pulmonary epithelia could activate endogenous pathways important in lung protection. METHODS AND ...

OBJECTIVE Neutrophils are an important component of the inflammatory response that characterizes acute lung injury (ALI). This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil activation in the setting of ALI. DATA SOURCES MEDLINE, original research pa...

Acute lung injury (ALI) is characterized by the influx of protein-rich edematous fluid into the airspaces due to increased permeability of the alveolar-capillary barrier. Inflammatory mediators are thought to play a critical role in the pathogenesis of this disorder. In this issue of the JCI, Zhao et al. report that the forkhead box M1 (FoxM1) transcription factor induces endothelial regenerati...