Alkyldihydroxyacetone-P (alkyl-DHAP) synthase, the enzyme that forms the ether linkage of alkyl and alk-1-enyl glycerolipids, has been solubilized from ehrlich ascites cell microsomes using Triton X-100 and acetone precipitation. the solubilized enzyme, which is stabilized by glycerol or ethylene glycol, was then purified further by chromatography on DEAE-cellulose, QAE-Sephadex, Matrex Red, an...

There is a great demand for development of catalyst systems that are not only efficient and highly enantioselective but are also environmentally benign. Herein we report investigations into the catalytic asymmetric addition of alkyl and functionalized alkyl groups to ketones under highly concentrated and solvent-free conditions. In comparison with standard reaction conditions employing toluene ...

[reaction: see text] Enantio- and diastereoselective syntheses of trans-2,5-disubstituted morpholine derivatives are described. The routes are initiated by the reaction of enantiopure epoxides (2) with amino alcohols (3) and address the problem of regioselective hydroxyl activation-ring closure of the resulting amino diol adducts for (amino alcohol-derived) alkyl substituents of different steri...

Highly efficient iridium catalyzed asymmetric transfer hydrogenation of simple ketones with ethanol as a hydrogen donor has been developed. By using chiral spiro iridium catalysts (S)- a series of alkyl aryl ketones were hydrogenated to chiral alcohols with up to 98% ee.

Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron-withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has...

Copper(ii) tetrasulfophthalocyanine supported on three-dimensional nitrogen-doped graphene-based frameworks was synthesized and introduced as a bifunctional catalyst for selective aerobic oxidation of alkyl arenes and alcohols to the corresponding carbonyl compounds. The ease of catalyst separation, high turnover, low catalyst loading and recyclability could potentially render it applicable in ...

An electrochemical system has been developed in order to assay the effect of hydrophobic molecules on the bioluminescence of bacterial luciferase (BL). The inhibition of BL luminescence by the long-chain n-alkyl alcohol has been examined using this system. The 1-heptanol, 1-octanol, 1-nonanol, 1-decanol, 1-undecanol and 1-dodecanol inhibited the BL reaction in a dose-dependent manner. The IC(50...

Alkyl hydroperoxides are reduced to alcohols in the presence of DPNH and homogeneous rubredoxin and rubredoxin-DPN reductase from Pseudomonas oleovorans. The reaction does not occur when TPNH is substituted for DPNH or when rubredoxins from anaerobic bacteria are substituted for the P. oleovorans nonheme iron protein. The reaction appears to have broad substrate specificity; 1-octyl, 2-octyl, c...

• A Cu-catalyzed 100% atom–efficient amidation and esterification reaction based on the of cyclopropenones with amines or alcohols, is shown. Both soluble solid Cu catalysts are catalytically competent, a Cu-containing metal–organic framework (MOF) particularly active reusable. The can be performed in variety solvents conditions, including water at different pHs, which defined as click reaction...

A stereospecific nucleophilic substitution between tertiary alkyl bromides and alcohols is described in the Research Article on page 4329 by Toshiki Nokami, Takashi Koike, Manabu Abe, Eiji Shirakawa, Nishikata, co-workers. The entering alcohol formally attacks C−Br bond to undergo a retentive with formation of ethers.