نتایج جستجو برای: allelic sequence variation
تعداد نتایج: 693824 فیلتر نتایج به سال:
We employed allele-specific expression (ASE) analyses to document biased allelic expression in maize (Zea mays). A set of 316 quantitative ASE assays were used to profile the relative allelic expression in seedling tissue derived from five maize hybrids. The different hybrids included in this study exhibit a range of heterosis levels; however, we did not observe differences in the frequencies o...
Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our g...
Gene expression is a complex trait determined by various genetic and nongenetic factors. Among the genetic factors, allelic difference may play a critical role in gene regulation. In this study we globally dissected cis (allelic) and trans sources of genetic variation in F(1) hybrids between two Arabidopsis thaliana wild accessions, Columbia (Col) and Vancouver (Van), using a new high-density S...
Background and Aims: The human leukocyte antigen-E (HLA-E) is a member of non-classical HLA class-I genes which is highly conserved through evolution. In general, so far 25 alleles of HLA-E have been described. However, the existence of only two allelic group; HLA-E*01:01 and HLA-E*01:03 have been demonstrated in all the populations. HLA-E*01:01 and HLA-E*01:03 differ only at codon 107 of exon ...
Disease-resistance genes encoding intracellular nucleotide-binding domain and leucine-rich repeat proteins (NLRs) are key components of the plant innate immune system and typically detect the presence of isolate-specific avirulence (AVR) effectors from pathogens. NLR genes define the fastest-evolving gene family of flowering plants and are often arranged in gene clusters containing multiple par...
Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate (EMS)-induced soybean (Glycine max) population, consisting of 21,600 independent M2 lines, was developed. Over 1,000 M4 (5) families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity ...
ij xixjδij , where xi is the frequency of the ith haplotype and δij is the fraction of nucleotides at which haplotypes i and j differ. It shouldn’t come to any surprise to you that just as there is interest in partitioning diversity within and among populations when we’re dealing with simple allelic variation, i.e., Wright’s F -statistics, there is interest in partitioning diversity within and ...
TP53 gene plays a critical role in the follow-up of different cancer cases, including diagnosis and treatment mutation P53 gene. It harms encoded protein less function types due to has many mechanisms eliminate cells, like apoptosis, cell cycle arrest, DNA repair. This study aims detect abnormality change sequence correlation with Mosul city extraction depends on manual description from blood, ...
Abstract Allelic imbalance (AI) occurs when alleles in a diploid individual are differentially expressed and indicates cis acting regulatory variation. What is the distribution of allelic effects natural population? Are all same? distinct? The approach described applies to any technology generating allele-specific sequence counts, for example chromatin accessibility can be applied generally inc...
We investigate three alternative selection-based scenarios proposed to maintain polygenic variation: pleiotropic balancing selection, G x E interactions (with spatial or temporal variation in allelic effects), and sex-dependent allelic effects. Each analysis assumes an additive polygenic trait with n diallelic loci under stabilizing selection. We allow loci to have different effects and conside...
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