نتایج جستجو برای: allogeneic stem cell transplantation

تعداد نتایج: 1894343  

Neda Naghavi

Introduction: During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. The first adult stem cells isolated from dental tissues were dental pulp stem cells (DPSCs). When transplanted with hydroxyl apatite/tri calcium phosphate (HA/TCP) powder, they formed a dentin-like structure...

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological disorders. Cyclosporine (CsA) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (GvHD). In this retrospective study, we evaluated the effects of CsA serum levels on the incidence of acute GvHD and transplant outcomes. 103 adult patients rece...

Journal: :Blood 2007
Nicolaus Kröger Anita Badbaran Ernst Holler Joachim Hahn Guido Kobbe Martin Bornhäuser Andreas Reiter Tatjana Zabelina Axel R Zander Boris Fehse

The JAK2-V617F mutation occurs in about 50% of patients with myelofibrosis and might be a reliable marker to monitor residual disease after allogeneic stem cell transplantation. We describe a new, highly sensitive (>or= 0.01%) real-time polymerase chain reaction (PCR) to monitor and quantify V617F-JAK2-positive cells after dose-reduced allogeneic stem cell transplantation. After 22 allogeneic s...

Journal: :iranian journal of immunology 0
behrouz nikbin immunogenetics lab, department of immunology mandana mohyeddin bonab hematology-oncology research center, shariati hospital, tehran university of medical sciences fatemeh talebian immunogenetics lab, department of immunology

tissue and cell transplantation are regarded as a popular procedure in clinical sciences, prospecting a new horizon for several incurable diseases. along with its usefulness, many ethical concerns accompany this development. the ethical issue of organ transplant is unique to the source used which includes: living related, living unrelated, cadaveric, and xenotransplant. obtaining organs has a s...

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for hematological disorders. Cyclosporine (CsA) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (GvHD). In this retrospective study, we evaluated the effects of CsA serum levels on the incidence of acute GvHD and transplant outcomes. 103 adult patients rece...

Journal: :Medicinski Pregled 2022

Introduction. Modern treatment of Hodgkin?s lymphoma has led to a cure in 60-90% patients. The problem are patients whom disease relapse occurs, or the is refractory initial therapy. standard application high-dose chemotherapy with autologous stem cell transplantation. However, about half experience failure after Despite new therapeutic modalities, relapses, so allogeneic transplantation method...

Journal: :Turkish journal of haematology : official journal of Turkish Society of Haematology 2011
Hakan Göker Burak Uz Yahya Büyükaşık Salih Aksu İbrahim Haznedaroğlu Nilgün Sayınalp Yasemin Karacan Fatma Tekin Osman İlhami Özcebe

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the triad of intravascular hemolysis, venous thrombosis, and cytopenia. Treatment of PNH is generally supportive. Bone marrow transplantation is the only curative therapy for PNH, but is associated with significant morbidity and mortality. Herein, we present a patient with PNH that received eculizumab, a humanized monoclonal antibody...

Journal: :Haematologica 2010
Maarten L Zandvliet J H Frederik Falkenburg Ellis van Liempt Louise A Veltrop-Duits Arjan C Lankester Jayant S Kalpoe Michel G D Kester Dirk M van der Steen Maarten J van Tol Roel Willemze Henk-Jan Guchelaar Marco W Schilham Pauline Meij

BACKGROUND Human adenovirus can cause morbidity and mortality in immunocompromised patients after allogeneic stem cell transplantation. Reconstitution of adenovirus-specific CD4(+) T cells has been reported to be associated with sustained protection from adenovirus disease, but epitope specificity of these responses has not been characterized. Since mainly CD4(+) T cells and no CD8(+) T cells s...

2010
Eleftheria Hatzimichael Mark Tuthill

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is...

Journal: :Clinical lymphoma & myeloma 2009
Simon Hallam John G Gribben

Stem cell transplantation in chronic lymphocytic leukemia (CLL) is an evolving field. Younger patients with high-risk disease might derive the greatest benefit from this approach and the availability of reduced-intensity conditioning regimens has made allogeneic stem cell transplantation more relevant to patients with CLL. Patient selection, timing of transplantation, and method of conditioning...

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