نتایج جستجو برای: alpha 1 antitrypsin a1at

تعداد نتایج: 2882257  

Journal: :Clinical chemistry 2011
Yuhong Chen Melissa R Snyder Yi Zhu Linda J Tostrud Linda M Benson Jerry A Katzmann H Robert Bergen

BACKGROUND α-1-Antitrypsin (A1AT) deficiency results from a genetic disorder at 2 common loci. Diagnosis requires quantification of A1AT and subsequent identification of the specific variant. The current algorithm of laboratory testing for the diagnosis of A1AT deficiency uses a combination of quantification (nephelometry), genotyping, and/or phenotyping. We developed a multiple reaction monito...

2017
Donald R Royall Safa Al-Rubaye Ram Bishnoi Raymond F Palmer

The latent variable "δ" (for "dementia") uniquely explains dementia severity. Depressive symptoms are independent predictors of δ. We explored 115 serum proteins as potential causal mediators of the effect of depressive symptoms on δ in a large, ethnically diverse, longitudinal cohort. All models were adjusted for age, apolipoprotein E, education, ethnicity, gender, hemoglobin A1c, and homocyst...

Journal: :iranian journal of biotechnology 2009
mahboobe ghaedi abbas sahebghadam lotfi masoud soleimani mehdi shamsara sare arjmand

in this study, in order to facilitate and accelerate the production of eukaryotic protein alpha 1-antitrypsin (aat) with correct post-translational modifications, a protein production system based on the transduction of cho and cos-7 cells using lentiviral vectors was developed. human aat cdna was cloned into a replication-defective lentiviral vector. the transgene aat-jred chimer was transferr...

Journal: :Respiration; international review of thoracic diseases 2012
Don Sin Stephan F van Eeden

inducing a proteolytic burden in the lung microenvironment. Under normal circumstances, A1AT and other antiproteases neutralize this threat posed by neutrophils. However, in A1AT deficiency, defenses are perturbed, leading to elastic degradation on lung tissue resulting in emphysema. While most COPD patients do not have A1AT, this genetic syndrome serves as a useful human model of how disturban...

Journal: :Journal of immunology 2014
Eileen Frenzel Sabine Wrenger Stephan Immenschuh Rembert Koczulla Ravi Mahadeva H Joachim Deeg Charles A Dinarello Tobias Welte A Mario Q Marcondes Sabina Janciauskiene

The angiopoietin-like protein 4 (angptl4, also known as peroxisome proliferator-activated receptor [PPAR]γ-induced angiopoietin-related protein) is a multifunctional protein associated with acute-phase response. The mechanisms accounting for the increase in angptl4 expression are largely unknown. This study shows that human α1-antitrypsin (A1AT) upregulates expression and release of angplt4 in ...

Journal: :avicenna journal of medical biotechnology 0

human alpha 1-antitrypsin (aat) cdna was obtained from hepg2 cell lines. after pcr and construction of expression vector ppiczα-aat, human aat was expressed in the yeast pichia pastoris (p.pastoris) in a secretary manner and under the control of inducible alcohol oxidase 1 (aox1) promoter. the amount of aat protein in medium was measured as 60 mg/l 72 hr after induction with methanol. results i...

Journal: :iranian journal of basic medical sciences 0
sadegh fattahi cellular and molecular biology research center, faculty of medicine, babol university of medical sciences, babol, iran department of biochemistry, faculty of science, university of sistan & baluchestan, zahedan, iran nasrin kazemipour department of biochemistry, faculty of science, university of sistan & baluchestan, zahedan, iran department of biochemistry, school of veterinary medicine, shiraz university, shiraz, iran mohammad hashemi department of clinical biochemistry, zahedan university of medical sciences, zahedan, iran masood sepehrimanesh department of biochemistry, school of veterinary medicine, shiraz university, shiraz, iran

objective(s):psoriasis is an autoimmune disease that appears on the skin. although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. the aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human to find valuable biomarkers. materials and methods: in a case-control s...

Journal: :Respiratory Medicine CME 2011

2016
Abdul Rehman Khan Fazli Rabbi Awan

CONTEXT Under normal physiological conditions, leptin regulates body weight by creating a balance between food intake and energy expenditure. However, in obesity, serum leptin levels increase and become defective to retain energy balance. EVIDENCE ACQUISITION Elevated serum leptin levels are regarded as an established marker of obesity. It is also reported that obese asthmatic patients have m...

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