background and objectives: nodular lesions of liver are usually neoplastic (primary or metastatic), although inflammatory lesions can occur. the objectives of this paper were to study the cytomorphological changes in various nodular lesions of liver and to correlate the cytomorphological findings with biochemical parameters especially serum alpha-fetoprotein. materials & methods:  a cross-...

Background Tumor markers have been a valuable tool for decades to aid in the diagnosis, treatment, and monitoring of oncological diseases.
 Objective To retrospectively analyze requisition pattern tumor marker requests at largest tertiary care center eastern Nepal.
 Method A retrospective hospital-based cross-sectional study was conducted obtain data 5 common i.e., Alpha-Fetoprotein (...

A two year old boy presented with precocious puberty associated with hepatoblastoma. Serum concentrations of beta human chorionic gonadotrophin and alpha-fetoprotein were raised. An aggressive chemotherapeutic regimen resulted in useful palliation and interesting changes in the beta human chorionic gonadotrophin and alpha-fetoprotein concentrations. In contrast to a previous report, the ultrast...

Although the function of alpha fetoprotein (AFP) has never been fully described, quantitative changes in serum levels have been used as a clinical screening tool. Many pathologic conditions, such as hepatocellular or yolk sac tumors and neural tube defects [1]. Although it is rare for a tumor of epithelial origin to produce alpha-fetoprotein, the possibility exists due to the nature of the huma...

Background Chronic hepatitis is an important problem worldwide, associating high morbidity and mortality, and hepatocellular-carcinoma is one of its most severe complications. Multiple studies have tried to identify biomarkers that would allow an earlier detection of hepatocellularcarcinoma (HCC), compared to imagistic exams. Such biomarkers are represented by alpha-fetoprotein (AFP), des-gcarb...