نتایج جستجو برای: als

تعداد نتایج: 27090  

Journal: :Journal of biochemistry and molecular biology 2003
Jong-Mo Yoon Moon-Young Yoon Young Tae Kim Jung-Do Choi

Acetolactate synthase (ALS) catalyzes the first common step in the biosynthesis of valine, leucine, and isoleucine. ALS is the target site for several classes of herbicides, including sulfonylureas, imidazolinones, and triazolopyrimidines. Two forms of ALS (designated ALS I and ALS II) were separated from barley shoots by heparin affinity column chromatography. The molecular masses of native AL...

Journal: :Investigative ophthalmology & visual science 2011
Jing-Xia Liu Thomas Brännström Peter M Andersen Fatima Pedrosa-Domellöf

PURPOSE To determine the impact of amyotrophic lateral sclerosis (ALS) on the extraocular muscles (EOMs) by examining the laminin isoform composition of the basement membranes (BMs) in EOMs and limb muscles from donors with ALS. METHODS Muscle samples collected at autopsy from ALS donors and from transgenic mice overexpressing human superoxide dismutase type I mutations (D90A or G93A), and ag...

Journal: :Journal of neurochemistry 2011
Laura E Gonzalez Mónica L Kotler Lucas G Vattino Eugenia Conti Ricardo C Reisin Kirk J Mulatz Terrance P Snutch Osvaldo D Uchitel

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a gradual loss of motoneurons. The majority of ALS cases are associated with a sporadic form whose etiology is unknown. Several pieces of evidence favor autoimmunity as a potential contributor to sporadic ALS pathology. To gain understanding concerning possible antigens interacting with IgGs from sporadic ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Eleonora Palma Jorge Mauricio Reyes-Ruiz Diego Lopergolo Cristina Roseti Cristina Bertollini Gabriele Ruffolo Pierangelo Cifelli Emanuela Onesti Cristina Limatola Ricardo Miledi Maurizio Inghilleri

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons that leads to progressive paralysis of skeletal muscle. Studies of ALS have revealed defects in expression of acetylcholine receptors (AChRs) in skeletal muscle that occur even in the absence of motor neuron anomalies. The endocannabinoid palmitoylethanolamide (PEA) modified the clinical conditions in one...

Journal: :Neuropathology : official journal of the Japanese Society of Neuropathology 2016
Joanna J Bury J Robin Highley Johnathan Cooper-Knock Emily F Goodall Adrian Higginbottom Christopher J McDermott Paul G Ince Pamela J Shaw Janine Kirby

Amyotrophic lateral sclerosis (ALS) is characterized by motor neurone loss resulting in muscle weakness, spasticity and ultimately death. 5-10% are caused by inherited mutations, most commonly C9ORF72, SOD1, TARDBP and FUS. Rarer genetic causes of ALS include mutation of optineurin (mt OPTN). Furthermore, optineurin protein has been localized to the ubiquitylated aggregates in several neurodege...

2017
Ting Zhou Tina Khorshid Ahmad Kiana Gozda Jessica Truong Jiming Kong Michael Namaka

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which involves the progressive degeneration of motor neurons. ALS has long been considered a disease of the grey matter; however, pathological alterations of the white matter (WM), including axonal loss, axonal demyelination and oligodendrocyte death, have been reported in patients with ALS. The present review examined mo...

2017
TING ZHOU KHORSHID AHMAD KIANA GOZDA MICHAEL NAMAKA

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which involves the progressive degeneration of motor neurons. ALS has long been considered a disease of the grey matter; however, pathological altera‐ tions of the white matter (WM), including axonal loss, axonal demyelination and oligodendrocyte death, have been reported in patients with ALS. The present review examined ...

2017
Shane Wald-Altman Edward Pichinuk Or Kakhlon Miguel Weil

Amyotrophic lateral sclerosis (ALS) is an incurable motor neurodegenerative disease caused by a diversity of genetic and environmental factors that leads to neuromuscular degeneration and has pathophysiological implications in non-neural systems. Our previous work showed abnormal levels of mRNA expression for biomarker genes in non-neuronal cell samples from ALS patients. The same genes proved ...

Journal: :iranian journal of public health 0
peivand bastani dept. of health services management, school of health management and information sciences, tehran university of medical sciences, tehran, iran. soudabeh vatankhah dept. of health services management, school of health management and information sciences, tehran university of medical sciences, tehran, iran ; health management and economics research centre, tehran university of medical sciences, tehran, iran. masoud salehi health management and economics research centre, tehran university of medical sciences, tehran, iran ; depart. of statistics and mathematics, school of health management and information sciences, tehran university of medical sciences, tehran, iran.

this study was designed to present and compare iranian hospitals` performance applying ratio analysis technique.this cross-sectional survey was conducted to present an instant image of 139 iranian hospitals` performance status applying ratio analysis as one of the non parametric technical efficiency assessment methods in 2008. data was collected using nine dimensional questionnaires supported b...

2017
Anna Drannik Joan Martin Randy Peterson Xiaoxing Ma Fan Jiang John Turnbull

Sonic hedgehog (Shh) is a morphogen essential to the developing nervous system that continues to play an important role in adult life by contributing to cell proliferation and differentiation, maintaining blood-brain barrier integrity, and being cytoprotective against oxidative and excitotoxic stress, all features of importance in amyotrophic lateral sclerosis (ALS). ALS is a fatal disease char...

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