Model biopolymers are powerful tools to guide the interpretation of physical properties in complex systems. (Pro-Pro-Gly)10, (PPG)10, is a collagen-model peptide, whose structure is known at high resolution. Herein, Raman microscopy data of (PPG)10 powders and single crystals are reported. The spectra interpretation leads to an accurate assignment of three well-resolved amide bands correspondin...

The ketimide anion R2C=N(-) is an important class of chemically robust ligand that binds strongly to metal ions and is considered ideal for supporting reactive metal fragments due to its inert spectator nature; this contrasts with R2N(-) amides that exhibit a wide range of reactivities. Here, we report the synthesis and characterization of a rare example of an actinide ketimide complex [Th(BIPM...

Most homogenous gold catalyses demand ≥ 0.5 mol% catalyst loading. Owing to the high cost of gold, these reactions are unlikely to be applicable in medium- or large-scale applications. Here we disclose a novel ligand design based on the privileged (1,1'-biphenyl)-2-ylphosphine framework that offers a potentially general approach to dramatically lowering catalyst loading. In this design, an amid...

The amide-directed synthesis of five-coordinate osmium alkylidene derivatives from alkynes is reported. These types of complexes, which have been elusive until now because of the tendency of osmium to give hydride alkylidyne species, are prepared by reaction of the dihydride OsH2Cl2(PiPr3)2 (1) with terminal alkynes containing a distal amide group. Complex 1 reacts with N-phenylhex-5-ynamide an...

two new samples of poly(amide-imide)/nanocomposites containing bicyclo segment and dibenzalaceton moiety in the main chain were synthesized by a solution intercalation technique. poly(amide-imide) (pai) 8 as a source of polymer matrix was synthesized by the direct polycondensation reaction of n,n´-bis(4-carboxyphenyl)bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic diimide 3 with 2,6-bis(4-amino...

some amide derivatives have been synthesized by the reaction of corresponding nitriles with potassium tert-butoxide as a nucleophilic oxygen source under ultrasonic irradiation. this new methodology provides good to excellent yields in short reaction times (15-90 min) at room temperature.

Previous studies have revealed that the glucoincretin hormone glucagon-like peptide-1 (GLP-1)(7-36)amide is metabolized by dipeptidyl peptidase-IV (DPP-IV) and neutral endopeptidase 24.11 (NEP) to yield GLP-1(9-36)amide and GLP-1(28-36)amide, respectively, as the principal metabolites. Contrary to the previous notion that GLP-1(7-36)amide metabolites are pharmacologically inactive, recent studi...

one pot solvent less synthesis of amidoalkylnaphthol derivatives via reaction of aldehydes, 2-naphthol and acetamide/urea in the presence of phenylphosphinic acid is  described. this methodology provides a simple synthetic route to amidoalkylnaphthols in good to high yields.