Dominant strains of lactic acid bacteria (LAB) isolated from honey bees were evaluated for their γ-aminobutyric acid (GABA)-producing ability. Out of 24 strains, strain Taj-Apis362 showed the highest GABA-producing ability (1.76 mM) in MRS broth containing 50 mM initial glutamic acid cultured for 60 h. Effects of fermentation parameters, including initial glutamic acid level, culture temperatur...

The primary inhibitory and excitatory amino acid neurotransmitters are gamma-aminobutyric acid (GABA) and glutamate, respectively. Despite their pervasiveness in brain function and sensory processes, the amino acid neurotransmitters have received limited attention in the study of autism and related developmental disabilities. While the ubiquity of GABA and glutamate pathways in the CNS suggests...

Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) glutamate play an important role in (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional of transmitters inhibition during flexibility. Healthy...

The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), activates a variety of receptors in all areas of the central nervous system (CNS). GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre and postsynaptic neuronal processes. There are three classes of GABA receptors. GABAA and GABAC receptors are ionotropic in n...

the activities of 4-aminobutyric-2-oxoglutaric acid transaminase (gaba-t) and succinate semialdehyde dehydrogenase (ssadh) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (cck-x)and/or caerulein (cln). gaba transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of gab a-t, succinate semialdehyde...

In the present study, the effect of GABA (γ-aminobutyric acid) receptor agonists and antagonists on morphine-induced antinociception was investigated in formalin test in rats. Intraperitoneal (i.p.) injection of different doses of morphine (1, 3, 6 and 9 mg/kg) and intracerebroventricular (i.c.v.) injection of different doses of muscimol (0.5, 1 and 2 g/rat) or baclofen (0.25, 0.5 and 1 g/rat) ...

INTRODUCTION y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. It mediates its effects via the specific interaction with the integral membrane proteins, the GABA receptors. GABA receptors can be classified according to their respective transduction mechanisms following activation, as the GABA and the GABAB receptor respectively. The focus of this review...

There is a recent trend of using lactic acid bacteria for the production gamma-aminobutyric (GABA). This study described method that combines fermentation and self-buffered whole-cell catalysis efficient GABA Levilactobacillus brevis CD0817. Upon completion fermentation, cells were recovered to conduct by which substrate L-glutamic was catalytically decarboxylated GABA. itself maintained acidit...

Succinic semialdehyde dehydrogenase (SSADH) deficiency or 4-Hydroxybutyric Aciduria is an autosomal recessive inherited disorder of amma-aminobutyric acid (GABA) degradation. It is characterized by developmental delay, infantile-onset hypotonia, cognitive impairment language deficit, and ataxia. Epilepsy, aggression, Hyperkinetic behavior, hallucinations, and sleep disturbances have been descri...