In the present studies, the influence of inducible nitric oxide synthase (NOS) inhibition with aminoguanidine on renal function and blood pressure was examined in rats. Intravenous aminoguanidine infusion (60 mg x kg-1 x hr-1) for 40 minutes to anesthetized Sprague-Dawley rats (n=7) resulted in no significant changes in mean arterial pressure or renal cortical blood flow, while medullary blood ...

We sought to determine whether expression of the inducible, calcium-independent isoform of nitric oxide synthase (iNOS) contributes to the tissue damage produced by focal cerebral ischemia. The middle cerebral artery was occluded in halothane-anesthetized spontaneously hypertensive rats. Twenty-four hours later rats received intraperitoneal injections of the iNOS inhibitor aminoguanidine (100 m...

BACKGROUND AND OBJECTIVE The present study aimed to assess the effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants in rats. MATERIAL AND METHODS Thirty-six rats were randomly divided into six groups: group 1, healthy rats (no aminoguanidine); group 2 and group 3, healthy rats receiving 10 and 20 mg/kg of aminoguanidine daily, respect...

abstract cancer is the leading cause of death worldwide. current anticancer drugs involve various toxic side effects; efforts are ongoing to develop new anticancer agents especially from the screening of natural compounds. present study investigated cytotoxic effects and mode of cell death induced by the caspian cobra venom in some human cancer cell lines. cytotoxic effects of snake venom toxin...

In the reaction of zinc(II) sulfate and chloride salt 2-acetylpyridine-aminoguanidine, two types complex were obtained, i.e., [Zn(H2O)6](H2L)2(SO4)3·3H2O [Zn(L)H2O(SO4)]·H2O, depending on presence LiOAc as deprotonating agent. The physicochemical, structural, photoluminescence properties complexes examined. first complex, obtained in absence LiOAc, Schiff base had role a counter-ion its doubly ...

Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...

Docetaxel (DTX) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. Though, its routine clinical administration, formulated in tween 80, causes serious side effects. Polylactide-co-glycolide (PLGA), biodegradable polyester synthesized and approved for human use, is employed to overcome this problem. In this investigation, we compare the cytotoxic m...

Docetaxel (DTX) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. Though, its routine clinical administration, formulated in tween 80, causes serious side effects. Polylactide-co-glycolide (PLGA), biodegradable polyester synthesized and approved for human use, is employed to overcome this problem. In this investigation, we compare the cytotoxic m...