Purpose: To evaluate the clinical efficacy of amniotic membrane extract eye drops (AMEEDs) in patients with persistent epithelial defects (PEDs) cornea.Methods: Sixteen PEDs refractory to conventional treatment were further treated AMEEDs six times a day. Visual acuity, visual analog scale (VAS), esthesiometer score, and areas before after 1 2 months evaluated. After months, considered effectiv...

PURPOSE To evaluate how sutureless amniotic membrane patches may affect visual functions in normal human eyes. DESIGN Prospective intervention study. METHODS Ten sets of sutureless amniotic membrane patch manufactured as PROKERA were inserted in one eye of six normal patients. Four sets (one each) were inserted in four patients, while six sets (three each) were inserted in two patients. Unc...

UNLABELLED Diabetic foot ulcers (DFUs) occur as a result of multifactorial complications and are commonly found in the diabetic community. Underlying disease states such as neuropathy and peripheral vascular disease can slow healing rates, potentially leading to recurrence, amputation, and increased mortality. As with many other disease processes, DFUs have several treatment options, such as de...

The amniotic membrane is the innermost layer of fetal membrane and is attached to the chorion in the placenta. This membrane has been used for nearly a century in varied fields such as ophthalmology, reconstructive surgery, and burn treatment. In this case report, we used a human amniotic membrane to repair an iatrogenic oroantral communication that occurred during the extraction of the patient...

Background: Equine wounds, particularly those involving the distal portion of the limbs, often undergo prolonged complex healing and may enter a non-healing state with obvious financial and welfare implications. Poor blood supply and lower levels of oxygen to the lower limbs lead to imbalance of growth factors related to wound healing. Decellular amniotic membrane has been widely used in soft t...

UNLABELLED The new defined anatomical and functional complex conjunctiva-limbus-cornea is a new concept, which helps clinicians better understand and treat ocular surface pathologies. The management of the ocular surface disease has changed dramatically over the years, with spectacular improvements of techniques, and of course, results. The amniotic membrane, used as a graft or as a substrate f...

Denuded human amniotic membrane is widely proposed to be used for retinal pigment epithelial cell transplantation. Notch signaling though important and known to have role in both health and disease of retinal pigment epithelial cells; is not well studied for retinal pigment epithelial cells cultured on denuded human amniotic membrane. The outcome of Notch signals is strictly dependent on the ce...

OBJECTIVE To determine whether amniotic membrane transplantation can be used to treat symptomatic bullous keratopathy displaying poor visual potential. METHODS Amniotic membrane transplantation was performed at 5 centers on 50 consecutive eyes (50 patients) with symptomatic bullous keratopathy and poor visual potential. The underlying causes of bullous keratopathy included aphakia (9 eyes), p...

© Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht 2015 R.C. Zhao (ed.), Stem Cells: Basics and Clinical Translation, Translational Medicine Research 1, DOI 10.1007/978-94-017-7273-0_2 Abstract Application of amnion membrane with multiple bioactive biomaterial has over 100 years of history. Amnion membraneand amniotic fluid-derived stem cells mainly in...