Naturally, deformed rocks commonly contain crack arrays (joints) forming patterns with systematic relationships to the large-scale deformation. Kinematically, joints can be mode-1, -2 or -3 or combinations of these, but there is no overarching theory for the development of the patterns. We develop a model motivated by dislocation pattern formation in metals. The problem is formulated in one dim...

Electron microscope study of rat mast cell maturation corroborates certain interpretations of features of mast cell differentiation based on light microscope studies. In addition, the ultrastructural variation observed in the granules of differentiating mast cells suggests that granule formation begins with the elaboration of dense granules about 70 mmicro in diameter inside Golgi vacuoles. The...

Toxoplasma gondii is an obligate intracellular parasite. When searching for a new cell to invade, the parasites have to confront the stress of being exposed to the extracellular environment. The mechanisms by which T. gondii survives outside the host cells are poorly understood. In this work we show that extracellular parasites form mRNA aggregates with characteristics of stress granules. Intra...

Previous communications from this laboratory delineated the events associated with the in vitro cultivation of unstimulated mouse mononuclear phagocytes (1, 2). These processes included a progressive increase in lysosome-like cytoplasmic granules. In addition, it was shown that two inhibitors of protein synthesis blocked the formation of both granules and hydrolytic enzymes. These data as well ...

Neurogenesis occurs throughout life in the subgranular zone of the dentate gyrus, and postnatal-born granule cells migrate into the granule cell layer and extend axons to their target areas. The α7*nicotinic receptor has been implicated in neuronal maturation during development of the brain and is abundant in interneurons of the hippocampal formation of the adult brain. Signalling through these...

Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many translation initiation factors, ribosomal subunits and mRNAs being sequestered into stress granules or P bodies. This allows the re-programming of the translation machinery. Many asp...

The granule cells of the dentate gyrus are a population of neurons continuously generated throughout life. In the rat, the morphological development of newly born granule cells generated in the adult share many similarities with granule cells generated during development. These include a specific migration pattern, orientation and progression of neurite outgrowth. It appears as though varied de...