INTRODUCTION Pain is a very well-known signal of ill health and analgesics are the drugs that are used to relieve pain. The main problem with these drugs remains that of side effects. Safer alternatives are natural herbs. Guduchi (Tinospora cordifolia) is one such plant with analgesic potential but few studies are there. OBJECTIVE To evaluate the analgesic activity of commercially available e...

Aim: To investigate the analgesic and anti-inflammatory properties of seed extracts of Diplocyclos palmatus (L) C. Jeffrey. Methods: Three extracts of different polarity of Diplocyclos palmatus (L) C. Jeffrey seeds were tested for their analgesic and anti-inflammatory activities. Analgesic activity was evaluated using the hot plate and acetic acid-induced writhing in mice. Antiinflammatory acti...

In investigating the development of compounds with potent analgesic effects after oral administration, 74 C-terminal analogues (N(alpha)-amidino-Tyr-D-Arg-Phe-X), based on the structure of N(alpha)-amidino-Tyr-D-Arg-Phe-Me beta Ala-OH (ADAMB), were synthesized. Their analgesic activity was evaluated using the mouse-tail pressure test after both subcutaneous and oral administration, and the stru...

The existence of glycine residues in long-chain scorpion toxins has been well documented. However, their role as analgesics has not been evaluated. To address this issue, we investigated the functional role of glycines in the C-terminal end of Chinese-scorpion toxin from Buthus martensii Karsch (BmK AGP-SYPU2) using site-directed mutagenesis and analgesic activity assays. Recombinant BmK AGP-SY...

A series of Schiff bases such as 2-(substituted phenylimino) quinoxaline-3-one were synthesized by nucleophilic addition reaction of quinoxaline-2,3-dione with p-Phenylene diamine followed by the Schiff reaction using different aldehydes in alcholol. A total of five compounds were synthesized by both conventional and microwave oven method with good percentage yield. They were purified and chara...

The ethyl acetate, chloroform extracts, and the two ‰avonoids kaempferol 1 and kaempferol-3-O-glucoside 2 isolated from whole plants of Thesium chinense Turcz were investigated for their antiin‰ammatory and analgesic activities. For the antiin‰ammatory activity, carrageenan-induced hind paw edema and xylene-induced mouse ear edema models, and for the analgesic activity, the acetic acid-induced ...

Oxazoline is one of the 5 membered heterocycle ring can be synthesized in many ways and various activities like analgesic, antimicrobial and antidiabetic activity are well documented. In the present study analgesic activity screened by tail flick and tail immersion model.The synthesized compounds are ideally characterized spectrophotometrically. Chlorinated and methoxylated oxazolines found to ...

[Met]Enkephalin-Arg6-Phe7 is an opiate-like peptide normally found in the the adrenal gland and brain that has analgesic (antinociceptive) activity when administered directly into the cerebral ventricles of mice. On a molar basis, [Met]-enkephalin-Arg6-Phe7, with a median effective dose (ED50) of 38.5 nmol/mouse, is 8 times more potent than [Met]enkephalin. As with [Met]enkephalin, analgesic ac...