To gain an understanding of the molecular pathogenesis of thyroid cancer, we used DNA microarray to study the expression profiles of 10 different human thyroid carcinoma cell lines. These included papillary lines BHP 2-7, BHP 7-13, BHP 10-3, BHP 18-21, NPA 87, and TPC1; anaplastic lines ARO 81-1 and DRO 90-1; follicular line WRO 82-1; and medullary line HRO 85-1. Among the genes with increased ...

Thyroid cancer (TC) is the most common endocrine tumor, with an annual incidence of 3.4% all cancers. An increasing described in recent years probably due to improved diagnostic techniques. It crucial identify type and stratify its risk. Among TC, papillary thyroid indolent best overall prognosis. However, there are some aggressively behaving TC that need be detected treated early. These includ...

Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhi...

Thyroid carcinoma accounts for the majority of deaths from endocrine cancers. Although effective therapies exist for well differentiated tumors, the treatment options for poorly differentiated and anaplastic tumors are much less effective. In the present study we demonstrate that the thyroglobulin (Tg) promoter can be used to direct specific expression of either luciferase or thymidine kinase i...

Anaplastic (undifferentiated) thyroid carcinoma is one of the most aggressive malignancies known to humans. It carries an almost uniformly fatal prognosis and, despite accounting for only 1.6% of thyroid malignancies in the United States, is responsible for more than half of all deaths attributed to thyroid cancer (1–3). Worldwide, anaplastic carcinoma constitutes 1–7% of all thyroid cancer cas...

OBJECTIVE The present study was done to evaluate the frequency of thyroid cancer and to find out the prevalence of histological types of thyroid tumor with respect to age and sex group. SETTING This study included consecutive cases of malignant tumors of thyroid gland, which were diagnosed in the Department of Pathology at the Aga Khan University Hospital, Karachi during the period of three y...

We report the immunohistochemical diagnosis, including TTF-1 (thyroid transcription factor 1) and Ki-67, of a rare mixed thyroid neoplasm composed of minimally invasive well differentiated follicular areas and highly aggressive undifferentiated anaplastic areas. A 75 old female presented to our clinic with a rapidly growing neck mass. Considering the dynamics of the disease and the multiple cha...