The tumor suppressor gene p16(INK4a) inhibits the kinase activity of the cyclin-dependent kinase 4-6/cyclin D complexes and subsequent phosphorylation of critical substrates necessary for transit through the G1 phase of the cell cycle. Recent studies suggested that control of the G1/S boundary might not be the sole biological function of p16(INK4a). We hypothesized that p16(INK4a) might influen...

Treatment of Class II malocclusions, without extractions, frequently requires distalization of maxillary molars into a Class I relationship by means of extra-oral or intraoral forces. Several methods and devices can be used to distalize maxillary molars and to correct Class II malocclusions. The most conventional method for distalizing the maxillary molars involves use of cervical headgear but ...

A clonal strain of human lung tumor cells in culture (ChaGo), derived from a bronchogenic carcinoma, synthesizes and secretes large amounts of alpha (alpha) and a comparatively lower level of beta (beta) subunit of the glycoprotein hormone, human chorionic gonadotropin (HCG). ChaGo cells lost their characteristic anchorage-independent growth phenotype in the presence of anti-alpha-HCG antibody....

AIM Conventionally, noncompliance distal movement of molars relies exclusively on intraoral anchorage. The distal screw, a distal jet appliance supplemented by two paramedian mini-implants, is an innovative alternative. The aim of this study was to evaluate the suitability of this device to move molars bodily and distally. METHODS The effects of the distal screw were evaluated in a sample of ...

The present study evaluated implant survival and marginal bone loss in maxillae over a 15-year follow-up period as a function of either monocortical or bicortical implant anchorage. Of 207 standard Brånemark implants (10 mm in length) followed, 110 implants were judged to be monocortically anchored and 97 as bicortically anchored. The bicortically anchored implants failed nearly 4 times more of...

OBJECTIVE To use published data to evaluate quantitatively the dental effects of noncompliance intramaxillary appliances in individuals with Class II malocclusion. MATERIALS AND METHODS A literature search was carried out identifing 13 prospective or retrospective clinical studies matching inclusion criteria. Only appliances with conventional anchorage designs were considered for the review. ...

Since the end of the 1970s, various appliances with intramaxillary anchorage for distalization of the upper molars have been described as an alternative to headgear. The major advantages of these innovative appliances are that they act permanently and are independent of patient compliance. The purpose of this study was to compare the efficiency, both quantitatively and qualitatively, of various...

Introduction: In orthodontic treatment, adequate anchorage is necessary to move the intended teeth. In some cases, just anterior teeth are malaligned, while posterior occlusion is acceptable. Therefore, the posterior teeth could be integrated by fiber-reinforced composite (FRC) to provide a rigid anchorage. This method proved advantageous since brackets are bonded just to anter...

objective: implants are being used in orthodontics as a reliable mode of anchorage. among other factors, the cortical bone thickness plays a major role in determining the stability of these implants. the objective of this study was to study the relationship of various arch forms and the cortical bone thickness and to determine if the cortical bone thickness varies between various arch forms. th...

In routine orthodontics practice anchorage is a critical factors that determining the success of an orthodontic treatment. For many years’ has been strenuous factor. Many modalities have tried for preventing loss by using extra oral and intraoral devices according to various scientific literature, yet orthodontists did not find any convenient solutions solve this problem until mini- implants we...