The estrogen-induced hamster renal carcinoma contains appreciable amounts of all cytosolic steroid receptor classes sedimenting as 7 to 8S moieties following sucrose gradient centrifugation. Their relative concentrations, expressed in fmol/mg protein +/- S.E. are progesterone (1496 +/- 23) greater than estradiol (218 +/- 3) greater than 5 alpha-dihydrotestosterone (154 +/- 7) greater than dexam...

Sir, Multiple myeloma is a monoclonal B-cell neoplasm, which is characterized by autonomous proliferation of immunoglobulin-secreting plasma cells, capable of synthesizing amyloidogenic light chains (AL). AL amyloidosis is characterized by extracellular deposition of eosinophilic, homogeneous, amorphous material composed of fibrillary protein, containing light chain fragments (1). The oral clin...

pected to be a mucinous cystic adenocarcinoma. We performed en bloc distal pancreatectomy and splenectomy. The macroscopic appearance was consistent with mucinous cystic neoplasm ( fig. 3 ). Microscopy showed epithelium composed of mucin-secreting cells and a dense cellular ovarian-type stroma ( fig. 4 ). Adenocarcinoma was A 41-year-old woman was referred to our hospital for evaluation of an a...

Pseudomyxoma peritonei (PP) is a rare clinical condition characterized by progressive mucinous ascites, which is typically caused by a mucin-producing neoplasm. Reports of radiation therapy (RT) in the management of PP are limited. We report a unique case of a 62-year-old woman with severe, end-stage, recurrent PP and a large, mucin-secreting mass protruding through her abdominal wall. Low-dose...

Pheochromocytomas are tumors of the neural crest-derived chromaffin cells. The hallmark of this rare and fascinating neoplasm is the synthesis and secretion of catecholamines in an unregulated and potentially life-threatening manner. Most pheochromocytomas produce an abundance of norepinephrine. Epinephrineor dopamine-secreting pheochromocytomas are less common.[1] Pheochromocytomas can also be...

Ectopic ACTH syndrome is a rare cause of Cushing's syndrome accounting for about 15% of all cases. Small cell lung cancer and bronchial carcinoids account for about half of the cases. Malignant neoplasm has rapid and more aggressive metabolic effects. We report a 54-year-old male patient with phenotypic features of Cushing's syndrome with severe hypokalemia, metabolic alkalosis, hypertension an...

The proinflammatory chemokine interleukin-8 (IL-8) is undetectable in androgen-responsive prostate cancer cells (e.g., LNCaP and LAPC-4), but it is highly expressed in androgen-independent metastatic cells, such as PC-3. In this report, we show IL-8 functions in androgen independence, chemoresistance, tumor growth, and angiogenesis. We stably transfected LNCaP and LAPC-4 cells with IL-8 cDNA an...

The incidence of hepatomas was markedly increased in goldthioglucose-obese CBA males as compared with nonobese controls. Goldthioglucose-induced obesity did not have as striking an effect on the incidence of liver tumors in females when compared with the males, even though the females weighed more than the treated males. Hepatomas appearing in obese intact females and castrated obese and contro...

CONTEXT Glucagonoma syndrome may present either associated with a pancreatic neoplasm which secretes glucagon or as a pseudo-glucagonoma associated with other diseases. It is extremely infrequent but well-known with a current prevalence estimated at 1/20,000,000. DESIGN A retrospective review of glucagonoma and pseudoglucagonoma cases observed between January 1998 and December 2003 in three h...