نتایج جستجو برای: animal testing alternatives
تعداد نتایج: 580515 فیلتر نتایج به سال:
The field of prenatal genetic testing has exploded with new non-invasive technologies and test options in the past several years. It is challenging for women's healthcare providers to keep up with the multitude of publications and provide patients with the most accurate and up-to-date information possible regarding prenatal testing. In this article, we examine the sequencing technologies that p...
Functional assessments of cardiovascular fitness (CVF) are needed to establish animal models of dysfunction, test the effects of novel therapeutics, and establish the cardio-metabolic phenotype of mice. In humans, the graded maximal exercise test (GXT) is a standardized diagnostic for assessing CVF and mortality risk. These tests, which consist of concurrent staged increases in running speed an...
OBJECTIVE To evaluate preferences and decision-making among high-risk pregnant women offered a choice between Non-Invasive Prenatal Testing (NIPT), invasive testing or no further testing. METHODS Nationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first-trimester combined testing (>1:200) or medical his...
341 t4 Workshop Report* A Framework Program for the Teaching of Alternative Methods (Replacement, Reduction, Refinement) to Animal Experimentation Mardas Daneshian 1, Mohammad A. Akbarsha 2, Bas Blaauboer 3, Francesca Caloni 4, Pierre Cosson 5, Rodger Curren 6, Alan Goldberg 7, Franz Gruber 8, Frauke Ohl 9, Walter Pfaller 10, Jan van der Valk 11, Pilar Vinardell , Joanne Zurlo , Thomas Hartung ...
Most conventional cell-based in vitro assays for the assessment of cell viability and cytotoxicity are disruptive endpoint assays requiring cell lysis. A non-invasive and label-free way to continuously monitor cellular behavior can now be achieved using the xCELLigence System of Real-Time Cell Analyzers (RTCA) co-developed by Roche and ACEA Biosciences (2). xCELLigence RTCA SP, MP and DP Instru...
Non-invasive prenatal testing (NIPT) is a technique first developed in the early 1990’s that enables testing of a fetus for genetic conditions, based on a sample of maternal blood [1]. Small fragments of extracellular DNA from both mother and fetus are present in maternal plasma, and by excluding fragments of maternal origin, the fetus can be tested for sex, aneuploidy and some specific genetic...
OBJECTIVE To evaluate the clinical performance of non-invasive prenatal testing for trisomy 21, 18, and 13 using targeted cell-free DNA (cfDNA) analysis. METHODS Targeted cfDNA analysis using DANSR™ and FORTE™ with microarray quantitation was used to evaluate the risk of trisomy 21, 18, and 13 in blinded samples from 799 singleton, twin, natural, and IVF pregnancies. Subjects either had fetal...
Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging
Ultrasound biomicroscopy (UBM) is a noninvasive multimodality technique that allows high-resolution imaging in mice. It is affordable, widely available, and portable. When it is coupled to Doppler ultrasound with color and power Doppler, it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer therapy. Target contrast ultrasound...
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