Sulfated polysaccharides from the egg jelly of sea urchins act as species-specific inducers of the sperm acrosome reaction, which is a rare molecular mechanism of carbohydrate-induced signal-transduction event in animal cells. The sea urchin polysaccharides differ in monosaccharide composition (l-fucose or l-galactose), glycosylation, and sulfation sites, but they are always in the alpha-anomer...

The synthesis of 1-thiotrehaloses and thioglycals by a directed copper-catalyzed dehydrogenative C?H thiolation the pseudo-anomeric bond glycals is described. use aminoquinoline-containing as well thiosugars or thiols coupling partners led to library thioglycosides in moderate good yields.

The empirical rules for estimating molar rotations of carbohydrate structures proposed by Whiffen and elaborated by Brewster provided interpretations of solvent effects on optical rotation with changes in conformational equilibria which in certain cases were confirmed by n.m.r. Conversely, it was found that only slight changes in rotation occur on changing the solvent for conformationally rigid...

NBO analysis, hybrid density functional theory (B3LYP/6-311+G**) and ab initio molecular orbital (HF/6-311+G**) based methods were used to study the anomeric effects (AE), electrostatic interactions, dipole-dipole interactions and steric repulsion effects on the conformational properties of 2-methoxy- (1), 2-methylthio- (2), 2-methylseleno- (3), 2-fluoro- (4), 2-chloro- (5) and 2-bromocyclohexa...

Meysam Yarie was born in 1987 in Malayer/ Hamedan, Iran. He received his B.Sc. in Applied Chemistry (2010) from Malek-Ashtar University of Technology and M.Sc. in Organic Chemistry (2012) from Kurdistan University under the supervision of Dr. Kamal Amani. He is currently working towards his Ph.D. under the supervision of Professor Mohammad Ali Zolfigol. His research interest is the synthesis, c...

Meysam Yarie was born in 1987 in Malayer/ Hamedan, Iran. He received his B.Sc. in Applied Chemistry (2010) from Malek-Ashtar University of Technology and M.Sc. in Organic Chemistry (2012) from Kurdistan University under the supervision of Dr. Kamal Amani. He is currently working towards his Ph.D. under the supervision of Professor Mohammad Ali Zolfigol. His research interest is the synthesis, c...

We herein show for the first time that the specific electronic character of a C-aglycone dictates the thermodynamic preference of the two-state N S pseudorotational equilibrium to either Nor S-type sugar. As the electron-deficiency of the C-aglycone increases, a more favourable O4'(n) σ*(C1'-C(sp2)) interaction results into anomeric stabilization as indicated by more positive ∆Η° for the drive ...