The hepatic circadian clock plays a key role in the daily regulation of glucose metabolism, but the precise molecular mechanisms that coordinate these two biological processes are not fully understood. In this study, we identify a novel connection between the regulation of RORγ by the clock machinery and the diurnal regulation of glucose metabolic networks. We demonstrate that particularly at d...

This investigation tested the hypothesis that metabolic syndrome decreases the relative contribution of specific K(+) channels to coronary reactive hyperemia. Ca(2+)-activated (BK(Ca)), voltage-activated (K(V)), and ATP-dependent (K(ATP)) K(+) channels were investigated. Studies were conducted in anesthetized miniature Ossabaw swine fed a normal maintenance diet (11% kcal from fat) or an excess...

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases. steatohepatitis (NASH), an advanced form of NAFLD, accompanies progression hepatic steatosis, inflammation, cell death, varying degree fibrosis. Interferons (IFNs) have been shown to play important roles in pathogenesis NAFLD NA...

Remimazolam, a novel, ultra-short-acting intravenous anesthetics, belongs to the benzodiazepine class of drugs and was approved for as general anesthetic. Its pharmacological action is similar that midazolam. However, differences in metabolic pathway pharmacokinetic profiles its metabolites contribute faster offset remimazolam than The context-sensitive half time (CSHT) short 6.8 ± 2.4 min. An ...

Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a "diet" devoid of pantothenic acid, with omega-methylpantothenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experiments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrit...

It is now recognized that the metabolic disorders observed in diabetes are not, or not only due to the lack of insulin or insulin resistance, but also to elevated glucagon secretion. Accordingly, selective glucagon receptor antagonists are now proposed as a novel strategy for the treatment of diabetes. However, besides its metabolic actions, glucagon also influences kidney function. The glucago...

PURPOSE Muscarinic acetylcholine receptors (mAChRs) have been implicated in the control of myopia in humans and in animal models. This study was conducted to determine whether mAChRs influence the growth of the chick sclera and, if so, which mAChR subtypes are involved. METHODS Sclera and scleral chondrocytes from normal and form-deprived eyes of 10- to 14-day-old chicks were treated with a t...

Objective(s): For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). Materials and Methods: Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretr...

in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...