Various extracts of Sarcostemma viminale were screened for central analgesic activity by hot plate test, peripheral analgesic activity by acetic acid-induced writhings, CNS depressant activity by pentobarbitone-induced sleep and locomotor activity testing methods and anthelmintic activity on the earthworms Pheretima posthuma . Results showed that petroleum ether and ethyl acetate extracts h...

Ethanolic and aqueous extracts of Bambusa vulgaris leaf were comparatively screened for anthelmintic activities; ethanolic extract appeared to be more potent in expelling the ova of Ascaris worm and the treated rabbits showed rapid weight gain with a mean value of 0.25kg after treatment as against 0.21g during infection than aqueous extracts. These suggest that they could serve as an alternativ...

In this review the available reports on drug resistance in human helminths, particularly hookworms and schistosomes, are critically analyzed. The experiences with helminths of livestock are then reviewed, in particular the factors contributing to the development of anthelmintic resistance, the mechanisms and genetics of resistance to various anthelmintic classes, and the methods available for d...

The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (FERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-meth ylleucyl-D-lactyl-L-N- methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic ...

Five different fused pyrazoles with nicotinoyl moiety and their inclusion complexes with β-cyclodextrin have been prepared. The formation of compounds and their inclusion complexes have been ascertained from the determination of melting point, elemental analysis and spectral properties. Finally, the compounds and their inclusion complexes have been screened for anthelmintic activities. It is fo...

The use of bioactive tanniniferous plants seems a promising alternative to control infections parasitic nematodes of the gastro intestinal tract in small ruminants. Both in vitro and in vivo studies, have confirmed the anthelmintic properties of several forage legumes, or tropical and browse plants. The aim of the present study was to evaluate the in vitro anthelmintic (AH) effect of 3 Tunisian...

There is no single requirement more crucial to the rational and sustainable control of helminth parasites in grazing animals than a comprehensive knowledge of the epidemiology of the parasite as it interacts with the host in a specific climatic, management and production environment. In its absence, anthelmintic treatment is either given suppressively, which provokes resistance, or therapeutica...

The rotation of different anthelmintic classes, on an approximately annual basis, has been widely promoted and adopted as a strategy to delay the development of anthelmintic resistance in nematode parasites. Part of the rationale for recommending this practice was the expectation that resistant genotype worms have a lower ecological fitness than susceptible worms, at least in the early stages o...

BACKGROUND Anthelmintic treatment is the most common way of controlling nematode infections in ruminants. However, several countries have reported anthelmintic resistance (AR), representing a limitation for sustainable small ruminant production. The knowledge regarding worm control management represents a baseline to develop a guideline for preventing AR. The aim of the present study was theref...

Parasitic gastroenteritis, caused by roundworms (nematodes), is well recognised as a major production-limiting disease, particularly in lambs. Effective parasite control has become heavily dependent on anthelmintics. The development of anthelmintic resistance by roundworms poses a potential crisis for sheep producers and measures to avert and delay this are essential. This report summarises the...