BACKGROUND The Women's Health Initiative randomized clinical trial reported that menopausal hormone therapy increases lung cancer mortality risk. If this is true, use of anti-estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast cancer patients with and without anti-estrogen therapy. METHODS Our study in...

objective: silybin is a polyphenol with anti-oxidant and anti-cancer properties. the poor bioavailability of some polyphenols can be improved by binding to phosphatidylcholine. in recent years, studies have been conducted to evaluate the anti-cancer effect of silybin. we studied the effect of silybin and silybin-phosphatidylcholine on esr1 and esr2 gene expression and viability in the t47d brea...

"All diseases resulting from qi disorder" comes out of Suwen. Jutonglunpian. This theory expounds the important influence abnormal lifting and entering machinery on disease. Breast cancer because movement disorders in Zang-fu meridian blood body fluid disorders, phlegm poison stasis do not become cancerous. Based "all disorder", this paper discusses etiology, pathogenesis treatment breast cance...

Biosynthesis of Silver Nanoparticles Using Hydroethanolic Extract Cucurbita pepo L. Fruit and Their Anti-proliferative Apoptotic Activity Against Breast Cancer Cell Line (MCF-7)

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...

Cancer is responsible for the death of millions people all around world. Among large group cancers, prevalence breast cancer highest in women. Therapeutic interventions, including removal surgery, radiation therapy, hormone and chemotherapy which largely used, may cause adverse effects on quality patients’ life. This fact has encouraged researchers to find natural substances such as honey overc...

Background: IL-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. Over production of IL-10 and elevated number of IL-10 generating mononuclear cells in breast tumor tissue has already been shown. Objective: To determine the association of IL-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors. Methods: Per...

OBJECTIVE Breast cancer recurrence may be promoted by immunosuppression due to decreased immune surveillance. The aim of this study was to examine the rates of breast cancer recurrence in patients with immune-mediated disease and treated breast cancer who received therapy with methotrexate, thiopurines, or anti-tumor necrosis factor (anti-TNF). METHODS Three retrospective cohort studies withi...

Objective(s):IL-12 as an anti-tumor cytokine and IL-33 a novel identified cytokine with both pro- or anti-tumor activities, play important roles in response against tumor cells. Our aim was to evaluate the IL-12 and IL-33 levels and single nucleotide polymorphisms (SNP) in their genes in patients with breast cancer. Materials and Methods:Blood samples were collected from 100 patients with breas...