OBJECTIVE The aim of this study was to assess the practice of pharmacotherapy of epilepsy and its treatment outcomes in adult epileptic outpatients at the University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia. METHODS An institution based, retrospective cross-sectional study was conducted from the medical charts of 336 adult epileptic patients at the outpatient epil...

Registry versus clinical trial The main goal of pregnancy registries includes the rapid identification of signals of increased teratogenic risk as quickly as possible, which is especially important for newly available anti epileptic drugs (AEDs) [1–3]. When the association between an increased risk and an AED is found in a registry, the cause can be further explored in a case–control study or a...

Epilepsy is one of the main causes of functional disability, and it is usually associated to psychiatric comorbidity, such as psychosis of epilepsy (POE). POE requires more careful pharmacological treatment, considering the propensity of the antipsychotics (AP) to provoke seizures and the risk of pharmacokinetic interaction with anti-epileptic drugs (AEDs). We discussed the classification and t...

oxidative stress has been suggested as a consequence and as a cause of epileptic seizures. researches indicate achillea wilhelmsii (a.wilhelmsii) has anti-oxidant and anti-spasmic effects on central nervous system. this plant grows in most part of iran. an iranian research that done in 2013 showed that the hydroalcoholic extract of achillea wilhelmsii possesses an antioxidant effect in the brai...

normal 0 false false false en-us x-none ar-sa approximately 1% of all pregnancies are in woman with epilepsy. although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. notably, the teratogenicity of antiepileptic drugs is a well-defined subject. the incidence of major malformations in offspring of mothers with epilepsy who were trea...

The aims of the present study were to investigate the effect of sodium valproate (VPA) on the sleep structures of epileptic patients and the correlation of these effects with patient weight gain. A total of 60 epileptic patients were divided into three groups: E-AED I (VPA administration for a duration of <3 months), E-AED II (VPA administration for a duration of >3 months) and ECO (without VPA...

Epilepsy is a common chronic neurological disorder that requires long-term or sometimes lifetime therapy. Recent evidence indicates that prolonged use of antiepileptic drugs (AEDs) might modify some vascular risk factors; however, the influence of AED therapy on the development of atherosclerosis has been the subject of controversy. Some epidemiological studies have reported a higher prevalence...