OBJECTIVES Celiac disease is one of the malabsorption syndromes leads to growth and development retardation in children. There is no test lonely can definitely diagnose celiac; however, the collection of clinical findings, serologic tests, intestinal biopsy, and response to treatment may diagnose it. Although diagnostic value is variable in different studies, they are used a non-invasive and ap...

Background: IgA serum autoantibodies against tissue transglutaminase (tTG) have an established diagnostic value in coeliac disease, and high efficacy tests are widely available for their detection. However, serological evaluation of IgA deficient subjects is still difficult. Aims: To evaluate the diagnostic potential of IgG class anti-tTG autoantibodies measured quantitatively using an enzyme l...

Sviluppo di immunosensori amperometrici e piezoeletrici per la rivelazione di anticorpi anti-tTG nella diagnosi della malattia celiaca Il presente lavoro riguarda la realizzazione di immunosensori a trasduzione amperometrica e piezoelettrica, basati sull’immobilizzazione della transglutaminasi tissutale in forma aperta (Open-tTG). Entrambe le strategie hanno permesso di ottenere un modello affi...

background: celiac disease (cd) may be misdiagnosed as irritable bowel syndrome (ibs) resulting in long delays in diagnosing cd. there are contradictory reports on the association of cd with ibs.appropriateness of screening all patients with ibs for cd and how to screen them are still under question. materials and methods: in a cross-sectional study, 328 ibs patients (rome ii) referred to the p...

BACKGROUND Recent guidelines have proposed that there is a correlation between tissue transglutaminase (tTG) antibody titers and degrees of duodenal biopsy, and that duodenal biopsy can be omitted in some patients with high levels of tTG antibody. Using data of registered patients in a gastrointestinal clinic we aimed to assess the correlation between tissue transglutaminase antibody with duode...

BACKGROUND The aim of our study is to evaluate if in children with highly positive serology and HLA-DQ2/DQ8 (triple test, TT) and only extra-intestinal symptoms, it is possible to omit performing an intestinal biopsy for celiac disease (CD) diagnosis, as suggested by the new European Society for Pediatric Gastroenterology, Hepatology and Nutrition ESPGHAN guidelines. METHODS In this retrospec...

PURPOSE Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this st...

Endomysial antibodies are a hallmark of coeliac disease. The existence of autoantibodies whose titres fluctuate with ingestion of gliadin is enigmatic.Gliadin seems to drive this antibody secretion as endomysial antibodies are produced in biopsy samples cultured with a peptic/tryptic digest of gliadin. The phenomenon of endomysial antibodies has been explained by molecular mimicry between gliad...

introduction: esophageal squamous-cell carcinoma (scc) is one of the most common malignancies in iran. to reduce the incidence of esophageal scc, it is important to recognize the controllable risk factors and prevent them. celiac disease is widely known as a possible risk factor for esophageal scc.  thus, we decided to assess the frequency of celiac disease in esophageal scc patients in north e...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: the prevalence of irritable bowel syndrome (ibs) in the community is 10%–20% and have symptom based diagnostic criteria. many symptoms of celiac disease (cd) with 1% prevalence in some communities can mimic ibs. sensitive and specific serologic tests of cd can detect asymptomatic cases. the purpose of this stud...