For screening of skin-whitening ingredients that modulate inhibition of melanogenesis, tyrosinase promoter-based assay using a three-dimensional (3D) spheroid culture technique is a beneficial tool to improve the accuracy of raw material screening in cosmetics through mimicking of the in vivo microenvironment. Although the advantages of high-throughput screening (HTS) are widely known, there ha...

In this study, the authors investigated the anti-melanogenic effects of 3,8-dihydroxyquinoline (jineol) isolated from Scolopendra subspinipes mutilans, the mechanisms responsible for its inhibition of melanogenesis in melan-a cells, and its antioxidant efficacy. Mushroom tyrosinase activities and melanin contents were determined in melan-a cells, and the protein and mRNA levels of MITF, tyrosin...

Abstract Purpose The interest in using bioresidues produced by the agri-food industry is increasingly intrinsic to world economy. As such, researchers started look for new ways enhance its use, developing innovations transform these residues into high-value raw materials with industrial application, promoting circular economy concept. Methods Therefore, pruning from production of Vaccinium myrt...

Trends in skin and hair treatments focus on natural products due to undesired effects of chemically synthetic ingredients. This study aims investigate the cosmeceutical Equisetum debile (horsetail) extracts relating anti-hyperpigmentation via tyrosinase, anti-wrinkle formation matrix metalloproteinases (MMPs), anti-androgenic alopecia 5α-reductase. Ethanolic were sequentially partitioned into s...

Background: Aging is a process caused by oxidants and aging-related enzymes. Therefore, the inhibition of these processes can exacerbate anti-aging agents. This study aimed to evaluate antioxidant activities leaf extracts from seven herbs used in traditional Thai herbal remedies. Methods: Researchers assessed total levels phenolic content (TPC), antioxidant, anti-collagenase, anti-tyrosinase ac...

Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase - a key enzyme in the pigmentation pathway. The tyrosinase enzyme is highly active in melanoma cells and metabolizes polyphenolic compounds; tyrosinase expres...

Natural products have the potential to be developed into new drugs for the treatment of various diseases. The aim of the present study was to screen the antioxidant activities of some common edible fruits, garden plants and medicinal plants indigenous to Taiwan. This was performed by assessing the activities of lipoxygenase, xanthine oxidase and tyrosinase following incubation with extracts fro...

The development of melanogenic inhibitors is important for the prevention of hyperpigmentation, and, recently, consideration has been given to natural materials or traditionally used ingredients such as Chinese medicine. The aim of this study is the evaluation of a new anti-melanogenic candidate, kadsuralignan F, from the natural plant Kadsura coccinea, as well as the determination of mechanism...

BACKGROUND/OBJECTIVES The root of Vitis amurensis Ruprecht, a sort of wild-growing grape, has been used in oriental medicine for treatment of skin ailments; however, its dermatological activity is not sufficiently understood. The aim of this study was to investigate tyrosinase inhibitory and anti-melanogenic activities of V. amurensis Ruprecht root methanol extract (VARM) in B16F10 mouse melano...

With the increasing number of cosmetic consumers emphasizing value consumption and sustainability, upcycling has gained attention as a solution to agricultural by-products, which are main culprits environmental problems. In this study, we isolated citrulluside T with whitening activity from discarded Citrullus lanatus stems investigated anti-melanogenic effect underlying mechanisms. We found th...