Objective(s): In previous studies, antioxidant activity of Viola odorata L. has been demonstrated. In this study, we have investigated the anti-melanogenic effect of extract and fractions of the plant in B16F10 cell line. Materials and Methods: Impact of different increasing concentrations of extract and fractions of V. odorata was evaluated on cell viability, cellular tyrosinase, melanin conte...

background tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants. it is also a key enzyme in melanin biosynthesis, which plays a crucial role in determining the color of mammalian skin and hair. in addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food ...

Cutaneous hyperpigmentation is a common disorder due to excess melanin production by the enzyme tyrosinase. The gold standard for treatment is hydroquinone (HQ), which reduces pigmentation through its toxicity to melanocytes rather than via tyrosinase inhibition. We screened an internal library for oligopeptides that inhibited both mushroom and human tyrosinase but showed no cytotoxicity to hum...

Because it promotes the lightening of pigment spots, tyrosinase inhibition is one mechanisms depigmenting cosmetic products. Considering adverse effects produced by synthetic actives, search for new therapeutic options desirable, and plant extracts are possible candidates hyperpigmentation treatment. Glycolic Cecropia pachystachya Trécul are, therefore, focus this study. Its chemical characteri...

Marine resources have various biological activities and their constituents are more novel than those of land organisms. Several biologically active been found in marine Recently, many studies reported that animals (MAs) can be used as functional ingredients foods or nutraceutical due to health benefits. However, no extensively investigated the cosmeceutical MAs extracts. Here, 70% ethanol extra...

The volatile organic compounds (VOCs) of two Coronilla species (Coronilla orientalis Miller and Coronilla varia L.) obtained by hydrodistillation (HD) and solid phase microextraction (SPME) techniques were identified by GC-FID/MS. The major compounds identified in the SPME extracts were limonene (43.4%) in C. orientalis, (Z)-β-ocimene and (E...

Objective(s): Tyrosinase is a key enzyme in pigment synthesis. Overproduction of melanin in parts of the skin results in hyperpigmentation diseases. This enzyme is also responsible for the enzymatic browning in fruits and vegetables. Thus, its inhibitors are of great importance in the medical, cosmetic and agricultural fields. Materials and Methods: A series of twelve kojic acid derivatives wer...

The results of the screening of thirty-one species belonging to the lichen family Graphidaceae for their ability to scavenge superoxide and inhibition of tyrosinase and xanthine oxidase activities have been presented. Graphina glaucorufa, Graphina multistriata, Graphina salacinilabiata, Graphis assamensis, Graphis nakanishiana and Phaeographopsis indica showed strong inhibition of tyrosinase an...

OBJECTIVES Nepeta binaludensis Jamzad (Lamiaceae) has been used in folk medicine of Iran to cure various diseases. The plant is an endemic species to the country that has recently been identified in Razavi Khorasan province. To evaluate the antioxidant and anti-melanogenesis of N. binaludensis, in this study the inhibitory activity of different extracts of N. binaludensis in murine melanoma B16...

Essential oils extracted from aromatic plants exhibit important biological activities and have become increasingly important for the development of aromatherapy for complementary and alternative medicine. The essential oil extracted from Cinnamomum cassia Presl (CC-EO) has various functional properties; however, little information is available regarding its anti-tyrosinase and anti-melanogenic ...