OBJECTIVES The purpose of this study was to determine the mechanism by which iron chelation affects the trophozoite survival of Entamoeba histolytica. Fe2+ is a cofactor for E. histolytica alcohol dehydrogenase 2 (EhADH2), an essential bifunctional enzyme [alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)] in the glycolytic pathway of E. histolytica. METHODS We tested the effects ...

to study the humoral immune response to entamoeba histolytica infection, sera prepared from different cases of amoebiasis from gastroenterology ward of b.h.u hospital, including15 cases with amoebic liver abscess (ala), 10 cases with acute amoebic dysentery (ad) and 10 controls were examined by enzyme linked immuno sorbent assay (elisa), using crude amoebic antigen prepared from entamoeba histo...

It is rather surprising that despite the ease of obtaining a rectal biopsy and considerable experience of this technique which exist in the routine diagnosis of neoplastic lesions in the rectum, it is only over the last two decades that its application in inflammatory lesions of the colon and rectum has become popular. As amoebiasis is very common in Madras, it had become a necessity to exclude...

It is rather surprising that despite the ease of obtaining a rectal biopsy and considerable experience of this technique which exist in the routine diagnosis of neoplastic lesions in the rectum, it is only over the last two decades that its application in inflammatory lesions of the colon and rectum has become popular. As amoebiasis is very common in Madras, it had become a necessity to exclude...

a tree of 10—20 m popularly known as tapiá, tanheiro-defolha redonda, tanheiro, or canela-raposa. It is found in the southern and southwestern regions of Brazil, mainly in the Atlantic pluvial forest. An ethnopharmacologic survey indicated that some species from the genus Alchornea are commonly used for the treatment of gastric diseases. Despite the common use of this species as a medicinal pla...

Acanthamoeba castellanii is a facultative pathogen that has a two-stage life cycle comprising the vegetatively growing trophozoite stage and the dormant cyst stage. Cysts are formed when the cell encounters unfavorable conditions, such as environmental stress or food deprivation. Due to their rigid double-layered wall, Acanthamoeba cysts are highly resistant to antiamoebic drugs. This is proble...

IMPORTANCE Acanthamoeba keratitis is a debilitating eye disease that requires effective topical drug therapy. Currently, there is no standard in vitro test to evaluate anti-Acanthamoeba drugs. OBJECTIVE To develop a practical in vitro complete-kill assay to assess anti-Acanthamoeba drugs. DESIGN AND SETTING Isolates of Acanthamoeba strains (n = 15) evaluated in a clinical laboratory. An in ...

Curcumin is coming from the Curcuma longa which gives golden color and have the biological importance. As per the survey it is water insoluble, the poor solubility and wettability of curcumin leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using di...