A novel nucleoside with an oxetanosyl-N-glycoside has been recently isolated from a culture filtrate from Bacillus megaterium and named oxetanocin A (N. Shimada, S. Hasegawa, T. Harada, T. Tomisawa, A. Fujii, and T. Takita, J. Antibiot. 39:1623-1625, 1986). In this study, we evaluated the antiherpesvirus activity of oxetanocin A and its derivatives and found that 9-(2-deoxy-2-hydroxymethyl-beta...

Neplanocin A, a novel cyclopentenyl analog of adenosine, is a naturally occurring antibiotic which exhibits significant antitumor activity against L1210 leukemia in mice (Yaginuma, S., Muto, N., Tsujino, M., Sudate, Y., Hayashi, M., and Otani, M. (1981) J. Antibiot. 34, 359-366). In the present study we demonstrate that neplanocin A is also a potent inhibitor of S-adenosylhomocysteine (AdoHcy) ...

background: tuberculosis (tb) is a major worldwide public health problem. the incidence of tuberculosis has decreased in iran in recent years. however, despite this dramatic decline, tuberculosis is still considered to be a major health problem in iran. objectives: the aim of this study was to investigate the epidemiological situation and main characteristics of tuberculosis in iran. patients a...

cockroaches were collected from hospitals, houses and poultry sheds in various parts of isfahan (iran) and identified to species. in total, seven species of cockroaches in seven genera were identified: blatta lateralis, polyphaga aegyptiaca, arenivaga roseni and parcoblatta spp. three species periplaneta americana, blattella germanica and supella longipalpa (blattidae and blattellidae) were mor...

conclusions according to the results, six strains were resistant to six or seven antibiotics and all strains were at least resistant to two antibiotics. however, for each of these resistant bacteria one bacteriophage was isolated from environmental samples, which showed the effectiveness of bacteriophages to remove clinically resistant e. coli strains. effective phages in vitro showed effective...

background and objectives: methicillin-resistant staphylococcus aureus (mrsa) is a major cause of nosocomial and community acquired infections. detection of mrsa in laboratories is very important for treatment and appropriate infection control. the aim of this study was to evaluate cefoxitin disk diffusion method for detection of mrsa and comparison of this method with other conventional method...

backgroundandobjectives:rapidandaccuratedetectionofmethicillinresistantstaphylococcus aureus (mrsa) is an important role of clinical microbiology laboratories to avoid treatment failure. the aim of this study was to compare conventional methods against the e-test minimum inhibitory concentration (mic) method to determine the best phenotypic method. materials and methods: methicillin resistance...

background: multi drug resistant (mdr) pseudomonas and acinetobacter species are defined as resistant to at least three classes of antibiotics. most studies have demonstrated that mdr gram negative infections convey increased mortality and morbidity. case: an 11-year –old girl was admitted to pediatric burns unit with burn injury of approximately 68% total body surface area (tbsa). discussion: ...

Tuberculosis (TB) is a disease of worldwide public-health concern. The development of resistance to an increasing number of second-line drugs and those used to treat multidrug-resistant (MDR) TB is rapidly becoming an emergency that could hinder the prevention and treatment of TB globally. This study describes the resistance profile of MDR and extensively drug-resistant (XDR) TB with a hospital...

Recently we reported on the rapid inactivation of tetracycline by use of cupric-morpholine complex (Kaplan, Lannon, and Buckwalter, J. Pharm. Sci., 64, 163, 1965). This degradation procedure is used as part of an assay technique for kanamycin in the presence of tetracycline. We have since found that sodium borohydride (Metal Hydrides Inc., Beverly, Mass.) can substitute for cupric-morpholine co...