Cefotaxime [HR 756], a third generation cephalosporin with pronounced antibacterial activity against the Enterobacteriaceae, was assessed in serious and problem antibiotic resistant infection. Good clinical success was achieved without observed untoward effects. The study suggests that due to its properties, cefotaxime could be used as a first-line antibiotic provided that the clinical situatio...

A new member of the monobactam family of beta-lactam antibiotics, designated MM 42842, has been detected in a culture of Pseudomonas cocovenenans. The production, isolation and some properties of the antibiotic are described. Structural studies show MM 42842 to be closely related to the previously described antibiotic sulfazecin.

Design, synthesis, and biological evaluation of several domains of the thiopeptide antibiotic thiostrepton led to the discovery of a biologically active fragment. The biological properties of this novel small organic molecule include antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF) bacterial strains, as well as ...

A new antibiotic swalpamycin (1) has been isolated from the culture broth of Streptomyces sp. Y-84,30967. The antibiotic has the molecular formula of C37H56O14 and belongs to the class of 16-membered neutral macrolide antibiotics. Its structure has been elucidated by an analysis of its spectral properties. It contains a novel aglycone herein called swalpanolide.

The survival of strains of Staphylococcus aureus on glass at 30 degrees C, 37 degrees C, and room temperature was compared with derivatives of them that had either lost or gained naturally occurring antibiotic resistance. In other properties the sets of strains were identical. Neither loss nor gain of antibiotic resistance (methicillin, penicillinase, streptomycin, tetracycline, erythromycin, n...

A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. On the basis of these data, the antibiotic was identified as the 10-car...

patients and methods two-hundred and fifty-five clinical specimens were collected from four major provinces of iran. samples were cultured and the mrsa strains were subjected to polymerase chain reaction (pcr). the patterns of antibiotic resistance were determined using the disk diffusion method. results seventy-four out of 255 (29.01%) clinical samples were positive for mrsa. of the 74 mrsa st...

Monensin (1), a carboxylic polyether antibiotic has been extensively used as an anticoccidial agent for poultry1} and to improve the efficiency of feed utilization in ruminant' animals2^. Despite the considerable economic and environmental implications of this extensive use in animals, few data are available on the detoxification processes of such molecules. Wedescribed recently the bioconversi...

medical compounds, especially antibiotics, in which remains in milk and dairy products on the one hand causes health problems such as allergic reactions and development of bacterial resistance to antibiotics are a serious threat to the health of consumers , and on the other hand, industrial troubles such as failure to produce fermented products can cause the milk back to the rancher. the purpos...