Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. ...

Cancer is a significant global healthcare problem, with an estimated worldwide incidence of 10 million new cases per year, 46% of which are in developed countries. Mortality is high, with >7 million deaths per year. The goal of cancer treatment is first to eradicate the cancer. If this primary goal cannot be accomplished, the therapeutic goal shifts to palliation, the amelioration of symptoms, ...

Synthesis of organometallic half-sandwich polypyridyl Ru and Rh complexes. Anticancer activity against resistant cancer cell lines effects ligand methylation on aqueous chemistry structure.

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

The recommendations for the practical stability of anticancer drugs published in 2010 by the French Society of Hospital Pharmacists (SFPO) and the European Society of Oncology Pharmacists (ESOP) have been updated. Ten new molecules have been included (asparaginase, azacitidine, bevacizumab, clofarabine, eribuline mesylate, folinate sodium, levofolinate calcium, nelarabine, rituximab, temsirolim...