Antidepressant drugs modify in different ways the activity of neurons, by increasing monoamines levels and by modulating ion channels. Sodium channels are molecular targets for antiepileptic drugs, which can also be mood stabilizers (i.e. lamotrigine, topiramate, phenytoin, carbamazepine, valproic acid). After a short overview on the sodium channels and the interaction with antidepressants and ...

Wir freuen uns, dass in diesem Jahr die hochkarätige Tagung der Gesellschaft für Medizinische Ausbildung [http://www.gesellschaft-medizinische-ausbildung.org] erstmals in der Steiermark stattfindet. Vom 26.-28. September 2013 wird sich an der Medizinischen Universität Graz alles rund um das Thema „Tradition: Hemmschuh oder Chance“ drehen [http:// www.gma2013.de]. Der Kongress bietet Ihnen dieMö...

Treatment-resistant depression is a common problem encountered by psychiatrists. These patients are often difficult to treat effectively. Strategies for addressing patients with treatment-resistant depression include changing medications, adding another antidepressant (antidepressant polypharmacy), and augmenting treatment with a non-antidepressant.

OBJECTIVE To define the risk of intracranial haemorrhage among patients treated with antidepressants and non-steroid anti-inflammatory drugs (NSAIDs), compared with the risk among those treated with antidepressants without NSAIDs. DESIGN Retrospective nationwide propensity score matched cohort study. SETTING Korean nationwide health insurance database between 1 January 2009 and 31 December ...

Classic antidepressants have been known to induce convulsive seizures and nonconvulsive status epilepticus (NCSE). On the other hand, many reports have emphasized the safety of novel antidepressants. However, we encountered three cases of NCSE in the elderly associated with the use of newer antidepressants at therapeutic doses. All three patients were male and were 73 years of age or older. One...

Es wird von mobilen Geräten mehr und mehr erwartet, die Fähigkeit zu haben, sich in vorhandene Umgebungen dynamisch integrieren zu können. Das soll möglichst ohne manuelle Konfiguration und auch später möglichst ohne manuellen Wartungsaufwand geschehen. Das System sollte „selbstkonfigurierend“ sein. In solchen Szenarien spontaner Vernetzung ist es wichtig, ein Mechanismus zu haben, welcher es e...

Little research has been done on the use of antidepressants among homebound older adults, especially low-income homebound older adults, and their perceptions of the effectiveness of their medication. The purposes of this study were to examine self-reported use of antidepressants among depressed homebound older adults, class and type of antidepressants used, individual-level correlates of antide...

Background In current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants' efficacy and harm, and these are barely recognized in treatment guidelines. The aim of this mini-review is to critically evaluate the efficacy and harm of antidepressants for acute and mainten...

OBJECTIVE A comprehensive meta-analysis of clinical trial data was performed to assess the possible association of fluoxetine and suicidality (suicidal acts and ideation). DESIGN Retrospective analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder comparing fluoxetine (n = 1765) with a tricyclic antidepressant (n = 731) or placebo (n = 569), or...