Interaction between the tricyclic antidepressant desipramine and the antihypertensive agent clonidine has been investigated in five hypertensive patients in a double-blind placebo controlled study. Introduction of the tricyclic antidepressant led to loss of blood pressure control in four of the patients. The average blood pressure rise in the desipramine period compared with the placebo period ...

According to the National Institute of Statistics, Geography and Computer Sciences (INEGI, Spanish acronym), in 2003, the method employed in suicide attempts was mostly drug ingestion. The ratio of adolescent boys and girls between 10 and 14 years old involved in suicide attempt is 1:1.3, while the ration of those in the same age range that successfully committed the suicide was 5 males:1 femal...

OBJECTIVES The study sought to describe whether psychotropic medication may have long-term side effects in patients with stroke compared with controls. SETTING Use of national register data from healthcare services were identified from the Danish National Patient Registry in Denmark. Information about psychotropic medication use was obtained from the Danish Register of Medicinal Product Stati...

OBJECTIVE To evaluate the use of a therapeutic regimen to treat attention deficit hyperactivity disorder patients. METHODS A total of 140 patients initially underwent physical, neurological and laboratory evaluation. Thereafter, treatment was initiated with a compounding product consisting of a tricyclic antidepressant and an anxiolytic. RESULTS The response was positive in 71.43% of patien...

Major depressionis one of the most commonclinicalproblemsseen by primary-carephysicians.The prevalenceis 5% to 10% in primary-careoutpatientsand 15% in medicallyill inpatients. Despite this high prevalence rate, depression is frequently not accurately diagnosed. Evidence suggests that misdiagnosis often occurs because patients with depression frequently focus preferentially on somatic complaint...

Clinical features and drug plasma concentrations were studied in 13 children admitted to hospital with tricyclic antidepressant poisoning. Patients with plasma concentrations below 500 microgram/l had anticholinergic signs and increased reflexes but did not have convulsions or cardiac arrhythmias. Four patients with plasma concentrations above 1000 microgram/l suffered convulsions, cardiac arrh...

In the treatment of fifteen patients with essential hypertension, in open trial indoramin caused a mean blood pressure fall from 180/115 mmHg to 159/98 mmHg. No reversal of antihypertensive effect was seen in four patients after additions of the tricyclic antidepressant drug desipramine. Blood pressure did not begin to rise in these four patients for at least 5 weeks after stopping indoramin. T...