The present study was carried out to investigate the pharmacokinetics and pharmacodynamic interaction of Aceclofenac and Rosiglitazone alone and their combination in rats. The animals were maintained on standard laboratory conditions and were divided into 3 and 6 groups for pharmacokinetic and pharmacodynamic studies respectively. Aceclofenac and Rosiglitazone alone produced antiarthritic and m...

BACKGROUND Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia generally associated with oxidative stress. The present study aims at evaluating the antioxidant and antidiabetic potential of methanol and hydroethanol extracts of the stem bark and leaves of Pricralima nitida and the Sonchus oleraceus whole plant respectively. METHODS The in vitro antioxidant ac...

Aloe vera gel has been claimed to have antidiabetic activity but not all published results are consistent. We investigated the effect of oral administration of one tablespoonful of Aloe vera juice, twice a day for at least 2 weeks in patients with diabetes. Blood sugar and triglyceride levels in the treated group fell; cholesterol levels were not affected. The results suggest the potential of a...

Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p<0.001) in blood glucose levels and was also found effective in restoring the blood lipid...

We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabetic rats, a marked antidiabetic activity was achieved. This effect was evidenced...

The oxidative stress mechanism in the body involves balance between increased ROS and decreased antioxidant agents. can damage DNA, proteins, lipids, leading to pathology impaired insulin secretion by dysregulation of several genes expression. High concentrations are often followed a low activity antioxidants from endogenous sources. As result, exogenous required neutralize ROS. reported, medic...

The present investigations evaluated the antioxidant and antidiabetic activity of Helicteres isora (L.) fruits belonging to the family Sterculiaceae. The hot water extract of Helicteres isora fruits was prepared and screened for its in vitro antioxidant activity using 1,1-diphenyl,2-picryl hydrazyl assay, ss-carotene-linoleate model and microsomal lipid peroxidation or thiobarbituric acid react...

Peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. Moreover, it is used to treat a variety of human ailments, including depression. This study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. A hydro alcoholic extract from seeds of this herb ...