نتایج جستجو برای: antigen presenting cells
تعداد نتایج: 1615635 فیلتر نتایج به سال:
Our rapidly expanding knowledge of the biology of the dendritic cell (DC), a major antigen-presenting cell connecting innate and adaptive immunity, suggests new possibilities for the development of vaccines and therapeutic strategies against pathogens, through the manipulation of their function in vivo, or the injection of the DC itself, once properly instructed ex vivo.
Antigen-presenting activity of non-Langerhans epidermal cells in contact hypersensitivity reactions.
Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non-Langerhans antigen-presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction. Following epicutaneous challenge with antigens, the number of CD1+DR+ epidermal Langerhans cells increased in a time-dependent way and, ...
It has been known for over 25 years that CD4 T cell responses are restricted to a finite number of peptide epitopes within pathogens or protein vaccines. These selected peptide epitopes are termed "immunodominant." Other peptides within the antigen that can bind to host MHC molecules and recruit CD4 T cells as single peptides are termed "cryptic" because they fail to induce responses when expre...
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While ...
Mesenchymal stem cells (MSC) possess a wide range of immunosuppressive functions. Among these is the ability to inhibit CD4+ T cell proliferation. Dendritic cells (DC) play a role in initiating cell-mediated immunity; however, the immunosuppressive influence of MSC on professional antigen presenting cells remains unclear. DC exposed to TNF-alpha and cultured with murine MSC failed to show regul...
Background: Tumor cells express antigens that can be recognized by immune system as foreign particles. Heat shock proteins (HSPs) are molecular chaperones that bind to tumor antigens and mediate their uptake into antigen presenting cells. Methods: This articles is a review article and its data has been collected and categorized from the articles in the field of cancer immunotherapy. All the ar...
Professional antigen-presenting cells, notably dendritic cells, play a key role in stimulating naive T cells--but nonprofessional antigen-presenting cells, such as fibroblasts, may also contribute to this process.
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