Ten patients with bronchial asthma were challenged with histamine before and after receiving saline and active drug (levomepromazine or antazoline) (a total of six challenges). The antihistaminic effect of levomepromazine (25 mg) was found to be comparable to that of antazoline (100 mg), evaluated from skin prick tests. Prechallenge forced expiratory volume in one second (FEV1) was found to be ...

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to gene...

In the present study, the effect of aqueous extract of Momordica dioica, aqueous extract of Myrica esculenta and ethanolic extract of Euphorbia hirta a lone and in combinat ion on h istamine induced bronchospasm in guinea p ig, milk induced leukocytosis and eosinophilia in mice and on antipruritic activity in mice was done. In the animal model o f h istamine induced bronchospasm , all plant sho...

The therapeutic efficacy and tolerance of ergoferon, an antiviral medication combining anti-inflammatory and antihistaminic actions were estimated in the treatment of adult patients with influenza and acute respiratory viral infection. Ergoferon was shown to stimulate production of endogenous interferon-alpha and interferon-gamma and to normalize the T-lymphocyte subpopulation composition and h...

The results of:' analysis of edema fluid and excised lungs show that there is leakage of protein-rich fluid into the lung tissue and ultimately into the respiratory passages. This leakage cannot be explained by the reduction in oxygen uptake as observed in lung tissue slices. The ultimate cause of pulmonary edema is not known. The survival time of anesthetized dogs suffering from thermal edema ...

Acute renal failure is an unusual complication of wasp stings. We report two cases of renal failure after multiple wasp stings (Vespa affinis). Both patients had evidence of intravascular haemolysis, hepatic dysfunction, oligo-anuria and azotaemia and required dialysis. The first patient had severe hemolysis, rhabdomyolysis, pigment and venom nephropathy and died on the 8th day in hospital. The...