Trichilia monadelpha (Thonn) JJ De Wilde (Meliaceae) bark extract is used in African traditional medicine for the management of various disease conditions including inflammatory disorders such as arthritis. The present study was undertaken to evaluate the anti-inflammatory properties of aqueous (TWE), alcoholic (TAE) and petroleum ether extract (TPEE) of T. monadelpha using the 7-day old chick-...

Epidemiological and laboratory studies indicate an inverse relationship between the risk of colon cancer development and intake of nonsteroidal antiinflammatory agents, including aspirin. One of the mechanisms by which nonsteroidal antiinflammatory agents inhibit colon carcinogenesis is through the inhibition of prostaglandin production by cyclooxygenase isozymes (COX-1 and COX-2). Overexpressi...

Antiinflammatory compounds are routinely used in veterinary medicine to manage traumatic injuries, provide analgesia, alter glucose metabolism, control allergies, and treat a variety of disease presentations. Historically, steroidal antiinflammatory agents were used to manage the majority of the cases described above; however, these compounds have lost favor in veterinary medicine because of th...

Juvenile idiopathic arthritis (JIA) is an umbrella term for seven or more clinical patterns of arthritis of unknown cause in children. Until the mid-1980s, therapy for children, with what was then called juvenile rheumatoid arthritis in the United States and juvenile chronic arthritis (JRA) elsewhere, consisted primarily of a small repertoire of antiinflammatory drugs and corticosteroids. Howev...

To the Editor: Although the Bier block has been used as a treatment for sympathetically-maintained pain (SMP) for many years, the selection of agents remains controversial. Different drug classes have been used, including alpha-adrenergic blockers (guanethidine, reserpine, bretylium), alpha-2 agonists (clonidine), nonsteroidal antiinflammatory agents (ketorolac, tenoxicam), local anesthetics (l...

The ethanol, methanol and water extracts of Tecoma stans effective against tested for antiinflammatory activity, lipoxygenase, xanthine oxidase and acetycholinesterase inhibitory activity. The methanol, ethanol and water extracts showed in vitro anti-inflammatory activity by inhibiting the heat induced albumin denaturation is 86.32, 83.81, 61.39 g/ml and red blood cells membrane stabilization w...