A 60-year-old man was admitted to our clinic with dyspnea, hemoptesis, anuria, nephritic syndrome, and a positive myeloperoxidase antineutrophil cytoplasmic antibody titer. He was diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis due to Wegener granulomatosis, microscopic polyangiitis, or drug induction. Unexpectedly, histopathologic examination of the kidney biopsy speci...

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Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmon...

Idiopathic pulmonary haemosiderosis remains a diagnosis of exclusion in patients who present with pulmonary alveolar haemorrhage. Systemic vasculitis developed in a patient with an eight year history of idiopathic pulmonary haemosiderosis. The diagnosis was confirmed by a rising titre of antineutrophil cytoplasmic antibodies directed against myeloperoxidase. Treatment with immunosuppressive age...

antineutrophil cytoplasmic autoantibodies (anca) were first described in patients with necrotizing glomerulonephritis. the original observation passed unnoticed until an association was made between anca and active wegener's granulomatosis. since then, tremendous progress has been made in elucidating the association between anca subtypes and clinicopathologic syndromes, and the potential p...

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