A model-based optimization methodology was developed to systematically address all possible optimal start-up scenarios of a multistage combined cooling and antisolvent continuous MSMPR (mixed-suspension, mixed-product removal) crystallizer. The crystallization aspirin (acetylsalicylic acid, ASA) in ethanol (solvent) water (antisolvent) used as case study. steady state firstly conducted optimize...

Deep eutectic solvents (DESs) have always been attractive to scientists due to their wide range of applications, a great interest in diverse fields including nanotechnology due to their unique properties as new green solvents. It used large-scale for chemical and electrochemical synthesis nanomaterial. DESs have had also active role in improving the size and morphology of nanomaterial during sy...

In this study, confined impinging liquid jets are used to produce nanoparticles of carbamazepine (CBZ). The effect of operating parameters, such as the kind of solvent,CBZ concentration, flow rate of solution and antisolvent on particle size, are experimentally investigated. The Scanning Electron Micrograph (SEM) photomicrographs show that nanodrug with smaller particle is achievable by usi...

We demonstrated the synthesis of ultra small and stable Cs3BiBr6 nanocrystals, ∼1.5–3 nm, via a room-temperature antisolvent method. Red-shift bandgap was observed in low temperature PL measurements with an activation energy ∼41 meV.

UNLABELLED BACKGROUND Effective pretreatment is key to achieving high enzymatic saccharification efficiency in processing lignocellulosic biomass to fermentable sugars, biofuels and value-added products. Ionic liquids (ILs), still relatively new class of solvents, are attractive for biomass pretreatment because some demonstrate the rare ability to dissolve all components of lignocellulosic b...

Objective: This study aims to develop and evaluate the phytosome of Phyllanthus emblica L. fruit extract. Methods: The formation was performed by using three methods, namely solvent evaporation, antisolvent, thin layer method. evaluated for its entrapment efficiency, particle size, polydispersity index, Fourier Transform Infra-Red (FTIR), Transmission Electron Microscope (TEM) methods. made int...

Posaconazole (PSZ) is a BCS (biopharmaceutical classification system) Class II anti-fungal drug used to treat infections in immunocompromised patients. The work presented herein describes the generation of cocrystals PSZ with 4-aminobenzoic acid (4AMB) using supercritical CO2 as an antisolvent GAS (Gas Antisolvent) acetonitrile, and solvent CSS (Cocrystallization Supercritical Solvent) methods....

PURPOSE This article investigated the influence of novel rifampicin nanosuspension (RIF NS) for enhancing drug delivery properties. METHODS RIF NS was fabricated using the antisolvent precipitation technique. The impact of solvent type and flow rate, stabilizer type and concentration, and stirring time and apparatus together with the solvent-antisolvent volume ratio on its controlled nanocrys...

The direct integration of crystalline oxide layers into flexible electronic systems requires the development relatively simple, low-temperature processing routes. Seeding represents a powerful strategy to reach this objective by generation preferential sites for nucleation phases with reduced energy barrier. Here, novel approach is reported where nanoseeds are generated in situ from precursor s...