نتایج جستجو برای: antitubercular activity

تعداد نتایج: 1136222  

Pyridazine plays a significant role in pharmaceuticals particularly in the field of medicinal chemistry. Several 4-substituted-benzylidene-6-substituted-phenyl-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-tetrahydro-pyridazin-3-ones (2) were prepar...

Journal: :Antimicrobial agents and chemotherapy 2015
Delia Blanco Esther Perez-Herran Mónica Cacho Lluís Ballell Julia Castro Rubén González Del Río José Luis Lavandera Modesto J Remuiñán Cindy Richards Joaquin Rullas María Jesús Vázquez-Muñiz Ermias Woldu María Cleofé Zapatero-González Iñigo Angulo-Barturen Alfonso Mendoza David Barros

One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gyrase inhibitors, which stem from the long-term efforts GSK has dedicated to th...

2014
B. Mathew J. Suresh Githa E. Mathew George Sonia G. K. Krishnan

A series of novel N-(furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimines (Fa-e) were synthesized and evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv) strain by using alamar blue assay. The synthesized compounds were characterized based on IR, (1)HMR and mass spectral analysis. The toxicity profile was predicted by organic chemistry portal, a w...

Tuberculosis (TB) is leading cause of death worldwide from infectious diseases and its inadequate treatment has led to emergence of resistant strains. The emergence of these strains renders the search for new drugs for the treatment of TB. The aim of this study was the evaluation of the anti-TB activity of the extract from fungus Gliocladium sp. MR41, and bioassay-guided fractionation and ident...

Journal: :Planta medica 2008
Dinesh Kumar Agrawal Dharmendra Saikia Richa Tiwari Shweta Ojha Karuna Shanker Jonnala Kotesh Kumar Anil Kumar Gupta Sudeep Tandon Arvind Singh Negi Suman Preet Khanuja

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strai...

Journal: :Zahedan Journal of Research in Medical Sciences 2015

Journal: :Molecules 2015
Dong Cai Zhi-Hua Zhang Yu Chen Xin-Jia Yan Liang-Jing Zou Ya-Xin Wang Xue-Qi Liu

A series of 5H-thiazolo[3,2-a]pyrimidin-5-ones were synthesized by the cyclization reactions of S-alkylated derivatives in concentrated H₂SO₄. Upon treatment of S-alkylated derivatives at different temperatures, intramolecular cyclization to 7-(substituted phenylamino)-5H-thiazolo[3,2-a]pyrimidin-5-ones or sulfonation of cyclized products to sulfonic acid derivatives occurred. The structures of...

Journal: :Memorias do Instituto Oswaldo Cruz 2009
Celso O R Júnior Mireille le Hyaric Cristiane F da Costa Taís A Corrêa Aline F Taveira Débora P Araújo Elaine F C Reis Maria Cristina S Lourenço Felipe R C Vicente Mauro V de Almeida

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

Journal: :archives of clinical infectious diseases 0
ravi ambey department of pediatrics, g.r. medical college, gwalior, india; department of pediatrics, g.r. medical college, gwalior, india. tel.: +91-7512403268 veerbhadra cd department of pediatrics, g.r. medical college, gwalior, india

we report 11 year old male child, a case of acquired aplastic anemia as a complication of disseminated tuberculosis with acute onset, rapid downhill course and refractory to both antitubercular drugs as well as immunosuppressive drugs.

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