The emergence of drug-resistant tuberculosis (TB) compromises global tuberculosis control. The incidence of multidrug-resistant strains (MDR) defined as resistant to the two main antituberculosis drugs, rifampicin and isoniazid, was raised in the 1990s. Ten percent of these strains have developed additional resistance to the main second-line antituberculosis drugs: fluoroquinolones and aminogly...

BACKGROUND The incidence of tuberculous pericarditis is increasing in Africa as a result of the human immunodeficiency virus (HIV) epidemic. The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis. METHODS AND RESULTS We searched MEDLINE (January 1966 to May 2005) and the Cochrane Library (Issu...

BACKGROUND MDR Mycobacterium tuberculosis is the major cause of treatment failure in tuberculosis patients, especially in immunosuppressed. We described a young polymyositis patient on immunosuppressive therapy who was started with antituberculosis therapy as a susceptible strain of M. tuberculosis was isolated from a single cutaneous abscess in his neck and from regional lymph nodes. CASE PR...

RATIONALE Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced hypersensitivity reaction characterized by skin rash, fever, blood abnormalities, and multiple organ involvement. The diagnosis of DRESS syndrome is often delayed because of its variable presentation. Prompt withdrawal of the culprit drug is the definitive treatment. DRESS syndrome induced ...

Although awareness of tuberculosis among captive elephants is increasing, antituberculosis therapy for these animals is not standardized. We describe Mycobacterium tuberculosis transmission between captive elephants based on whole genome analysis and report a successful combination treatment. Infection control protocols and careful monitoring of treatment of captive elephants with tuberculosis ...

Tuberculosis Arthritis of the knee joint is rare. A 25-year old female patient presented with pain andswelling her left knee. The symptoms first appeared two months earlier; she was given glucocorticoidafter diagnosed Rheumatoid Arthritis. did not improve treatment. wasdiagnosed tuberculosis arthritis according to biopsy and PCR TB result. Biopsy excision kneefound granulomatous appearance, whi...

The article describes the clinical case reports of patients with respiratory tuberculosis who were hospitalized at Regional Clinical Antituberculosis Center in Kursk. One them was pediatric department for organs and other 1st multidrug-resistant tuberculosis. As pathogenetic therapy complex treatment pulmonary tuberculosis, intensive phase anti-tuberculosis chemotherapy, we added inhalation sur...

Abstract Antituberculosis drug‐induced liver injury (ATDILI) has received increasing attention globally, which may limit the effectiveness of antituberculosis (anti‐TB) treatment. Many host genetic determinants ATDILI have been identified recently. As little knowledge is currently available about association between aldehyde dehydrogenase 1 family member A1 (ALDH1A1) polymorphisms and ATDILI, t...