نتایج جستجو برای: ap 1
تعداد نتایج: 2767098 فیلتر نتایج به سال:
Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates transcription at AP-1 sites that bind the Jun/Fos transcription factors, but not ER. We review the evidence regarding mechanisms whereby ER increases the activity of Jun/Fos and propose two pathways of ER action d...
The AP-1-binding sequences are promoter/enhancer elements that play an essential role in the induction of many genes in mammalian cells; however, the number of genes containing AP-1 sites remains unknown. In order to better address the overall effect of AP-1 on expression of genes encoded by the entire genome, a genome-wide analysis of the frequency and distribution of AP-1 sites would be usefu...
Activator protein-1 (AP-1) is a transcription factor that consists of diverse group members including Jun, Fos, Maf, and ATF. AP-1 involves number processes such as proliferation, migration, invasion in cells. Dysfunctional activity associated with cancer initiation, development, invasion, migration drug resistance. Therefore, potential target for targeted therapy. Currently, some small molecul...
Introduction: Glioblastoma is an aggressive malignancy of human brain with poorly understood pathogenesis. Voltage-gated potassium (Kv) channels and Matrix metalloproteinases (MMPs) are highly expressed in malignant tumors and involved in the progression and metastasis of glioblastoma. The purpose of this study was to determine whether a voltage-dependent potassium channel blocker could modulat...
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