نتایج جستجو برای: apamin
تعداد نتایج: 791 فیلتر نتایج به سال:
The apamin binding protein was solubilized from rat brain synaptic membranes using sodium cholate. Receptor yield and stability depended closely on the detergent/protein ratio. In optimum conditions the receptor retained high affinity for mono 125I-iodoapamin with Kd = 40 pM at pH 7.5 and 1 degree C and a binding capacity of 17 fmol/mg protein. 125I-apamin binding was stimulated by K+ ions with...
Small-conductance Ca2+-activated K+ channels (SK channels) are insensitive to the change of membrane potential and widely expressed throughout the nervous system in mammals [1-4]. There are three subtypes (SK1, SK2 and SK3) of SK channels and all of them have been found to express in the mammalian brain [1]. These channels are activated by rises in intracellular calcium concentration and can be...
Leiurotoxin I (scyllatoxin) is a 31-amino acid polypeptide from the venom of the scorpion Leiurus quinquestriatus hebraeus which has been previously isolated and sequenced by others. This paper reports (i) the total synthesis of this scorpion neurotoxin as well as some aspects of its structure-function relationships; (ii) the synthesis of the analog [Tyr2]leiurotoxin I (scyllatoxin) that has be...
Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 recepto...
Cholinergic dysfunction is a hallmark of Alzheimer’s disease (AD). This dysfunction is assumed to be mainly responsible for the cognitive defects in AD. However, the mechanism by which the cholinergic system regulates cognitive functions is elusive. This study was designed to find out the role of the septohippocampal cholinergic system in cognitive functions. The methods used were behavioural t...
BACKGROUND Apamin sensitive potassium current (I KAS), carried by the type 2 small conductance Ca(2+)-activated potassium (SK2) channels, plays an important role in post-shock action potential duration (APD) shortening and recurrent spontaneous ventricular fibrillation (VF) in failing ventricles. OBJECTIVE To test the hypothesis that amiodarone inhibits I KAS in human embryonic kidney 293 (HE...
Purinergic and nitrergic neurotransmission predominantly mediate inhibitory neuromuscular transmission in the rat colon. We studied the sensitivity of both purinergic and nitrergic pathways to spadin, a TWIK-related potassium channel 1 (TREK1) inhibitor, apamin, a small-conductance calcium-activated potassium channel blocker and 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one (ODQ), a specific inhi...
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