نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

Journal: :Blood 1999
A Inbal D Freimark B Modan A Chetrit S Matetzky N Rosenberg R Dardik Z Baron U Seligsohn

Several recent studies evaluated a possible effect of the prothrombotic polymorphisms such as 5,10 methylenetetrahydrofolate reductase (MTHFR) nt 677C --> T, factor V (F V) nt 1691G --> A (F V Leiden), and factor II (F II) nt 20210 G --> A on the risk of myocardial infarction. In the present study, we analyzed the effect of these prothrombotic polymorphisms, as well as apolipoprotein (Apo) E4, ...

Journal: :journal of research in medical sciences 0
hamid mirmohammad sadeghi associate professor, isfahan pharmaceutical sciences research center, isfahan university of medical sciences, isfahan, iran ali mohammad sabzghabaee associate professor, isfahan clinical toxicology research center, isfahan university of medical sciences, isfahan, iran zeinab mousavian pharmacy student, school of pharmacy, isfahan university of medical sciences, isfahan, iran mohammad saadatnia associate professor, department of neurology, school of medicine, isfahan university of medical sciences, isfahan, iran shahin shirani assistant professor, department of cardiology, school of medicine, isfahan university of medical sciences, isfahan, iran fatemeh moazzen research assistant, department of pharmaceutical biotechnology, school of pharmacy, isfahan university of medical sciences, isfahan, iran

background : apolipoprotein e (apoe) gene encodes an important protein in reforming injuries of central nervous system (cns). it is assumed that various apoe alleles may be functionally different. the purpose of this study was to investigate the distribution of apoe genotypes in multiple sclerosis (ms) patients in a small cohort of iranians. methods : in this case-control study, blood samples o...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2007
A K Fuzikawa S V Peixoto M Taufer E H Moriguchi M F Lima-Costa

Apolipoprotein E (ApoE) is one of the most extensively studied genes in the context of aging, but there are few population-based studies on ApoE polymorphism in the elderly in developing countries. The objective of the present study was to assess ApoE allele and genotype distribution in a large elderly community-based sample and its association with age, sex and skin color. Participants include...

2013
GODWIN O. IFERE RENEE DESMOND WENDY DEMARK-WAHNEFRIED TIM R. NAGY

High circulating cholesterol and its deregulated homeostasis may facilitate prostate cancer progression. Genetic polymorphism in Apolipoprotein (Apo) E, a key cholesterol regulatory protein may effect changes in systemic cholesterol levels. In this investigation, we determined whether variants of the Apo E gene can trigger defective intracellular cholesterol efflux, which could promote aggressi...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
H Tenkanen M Lukka M Jauhiainen J Metso M Baumann L Peltonen C Ehnholm

Apolipoprotein (apo) A-IV is a protein involved in the metabolism of chylomicrons and high density lipoproteins. This protein displays genetic polymorphism due to two main codominant alleles, A-IV1 and A-IV2. We have identified the mutation that leads to this polymorphism. It is caused by a single-base substitution of guanine for thymine in the third base of codon 360. This substitution leads t...

2011
I. DJAN EDITA STOKIĆ D. SAKAČ MIHAJLA DJAN DRAGANA OBREHT M. ERAK NATAŠA JOVANOVIĆ

Apolipoprotein E displays polymorphism with three common alleles, e2, e3, and e4. The aim of this research was to determine apoE gene polymorphism in a group of healthy patients and a group of patients with CHD, and to reveal the relation between anthropometric and biochemical parameters and the apoE genotype. In CHD group significantly higher values of blood pressure, waist circumference, BMI ...

Journal: :Clinical chemistry 2001
J Rubin T A Pearson R G Reed L Berglund

BACKGROUND The apolipoprotein(a) [apo(a)] gene is a major predictor of plasma lipoprotein(a) concentrations, an independent risk factor for cardiovascular disease. The apo(a) gene contains a pentanucleotide repeat (PNR) polymorphism, 1.4 kb upstream from the apo(a) gene reading frame. This polymorphism has been suggested to be important in control of apo(a) gene expression. METHODS We develop...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1994
A von Eckardstein H Funke A Chirazi C Chen-Haudenschild H Schulte R Schönfeld E Köhler S Schwarz A Steinmetz G Assmann

In Caucasians, a histidine for glutamine substitution (Gln-->His) at residue 360 in apolipoprotein (apo) A-IV leads to an electrophoretically detectable polymorphism whose contribution to lipid metabolism regulation is controversial. In this study of 426 male and 188 female coronary heart disease patients, we analyzed the impact of this polymorphism on lipid metabolism, particularly high-densit...

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