abstractthe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of anthocephalus cadamba (meac) on dalton’s lymphoma ascites (dla) cells treated mice. determination of antiproliferative activity was performed by using different dla cells (2×106 cells, i.p.) inoculated mice groups (n=12). groups were treated for 14 consecuti...

Objective: To determine the effect of convallatoxin on K562 cell proliferation and apoptosis. Methods: CCK-8 assay was used to detect proliferation; PI staining, JC-1 Annexin V-FITC/PI double staining were analyze cycle, mitochondrial membrane potential, apoptosis; Western blotting cleaved caspase-9, caspase-3, Bcl-2, Bax, E2F1 expression Akt phosphorylation. Subsequently, AutoDock software int...

Purpose: To investigate the anticancer effects of sparteine against human cervical cancer.
 Methods: Cell viability was determined by CCK8 assay, while 4′, 6-diamidino-2-phenylindole (DAPI) staining used for determination apoptosis. cycle analysis done with flow cytometry, cell invasion monitored using Transwell assays. Protein expressions were Western blotting.
 Results: The results ...

Cetuximab is a powerful anti-neoplastic agent that can inhibit cell growth in oral squamous carcinomas (OSCCs). Unfortunately, there are cases with unfavorable outcomes. Because few studies have focused on the combined effects of cetuximab and histone deacetylase (HDAC) inhibitors, we aimed to evaluate antitumor effect combination HDAC inhibitors human OSCC lines, investigate mechanism apoptosi...

Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific ant...

The major challenge to treat Parkinson’s disease (PD) is penetration of target molecule into the brain to improve the efficacy of drugs. To achieve better brain penetration and targeted delivery, 1,9-Pyrazoloanthrone (1,9-P) loaded liposomes were developed by solvent injection technique using ultrasonication and evaluated for particle size, morphology, entrapment efficiency, FT-IR, and in-vitro...

conclusions this study delineated the beneficial role of rsv for growth regulation of skin cancer cells and highlighted the involvement of rsv in the induction of apoptosis in a431 cells. these findings might conduct evidence into the oncolytic properties of rsv in the skin cancer. further studies are required to indicate intracellular targets for rsv-induced apoptosis in skin cancer cells. res...

Introduction It has been reported that the NF-κB and MMP-9 signaling pathways were involved in pathogenesis of osteoarthritis (OA), while treatment OA by YSY01 could inhibit proteasome activity. Therefore, we aimed to study therapeutic effect YSY01A on via interfering with expression MMP-9. Material methods Western blot analysis immunohistochemistry (IHC) assays used measure animal models estab...

Alcoholic liver disease (ALD) is a global that manifests in variety of forms, including alcoholic hepatitis, inflammation, fatty liver, and cirrhosis. One the early stages ALD (AFL) disease, which primarily characterized by accumulation lipids inflammation hepatocytes. Guanylate binding protein 5 (GBP5) has been investigated for its involvement progression. The regulatory effects GBP5 on progre...

Glioblastoma is most common and most aggressive cancer of brain. for treatment surgery is first selection and radiation therapy then chemotherapy. The median survival of Patients with GBM is less than a year after diagnosis. Glioblastoma is basically resistant to common cancer treatments. today to improve the response of patients to treatment, a number of strategies such as the use of radiation...