TNF-related apoptosis inducing ligand (TRAIL) is a promising anticancer agent because of its ability to selectively induce apoptosis in cancer cells but not in most normal cells. However, some cancer cells are resistant to TRAIL cytotoxicity thereby limiting its therapeutic efficacy. Using genome-wide mRNA expression profiles from the NCI60 panel and their differential sensitivities to TRAIL-in...

Half of trauma deaths are attributable to hypovolemic circulatory collapse (HCC). We established a model of HCC in rats involving minor trauma plus severe hemorrhagic shock (HS). HCC in this model was accompanied by a 50% reduction in peak acceleration of aortic blood flow and cardiomyocyte apoptosis. HCC and apoptosis increased with increasing duration of hypotension. Apoptosis required resusc...

Acute erythroleukemia is a rare form of acute myeloid leukemia recognized by its distinct phenotypic attribute erythroblasts proliferation. In this study, in vitro experiments showed that newly synthesized chalcone (ZH-254) inhibited cell proliferation, caused apoptosis, arrested the cycle G1 phase, and downregulated Fli-1 expression inhibiting promoter activity. vivo ZH-254 could effectively a...

Background: Mammalian cell division is regulated by a complex includes cyclin-dependent kinases (Cdks) and cyclins, Cdk/cyclin complex. The activity of the complex is regulated by Cdk inhibitors (CKIs) compressing CDK4 (INK4) and CDK-interacting protein/kinase inhibitory protein (CIP/KIP) family. Hypermethylation of CKIs has been reported in various cancers. DNA methyltransferase inhibitors (DN...

Stabilized melanocortin analog peptide ACTH(6–9)PGP (HFRWPGP) possesses a wide range of neuroprotective activities. However, its mechanism action remains poorly understood. In this paper, we present study the proproliferative and cytoprotective activity adrenocorticotropic hormone fragment 6–9 (HFRW) linked with prolyine–glycyl–proline on SH-SY5Y cells in model oxidative stress-related toxicity...