Understanding the molecular mechanisms underlying amyloid precursor protein family (APP/APP-like proteins, APLP) function in the nervous system can be achieved by studying the APP/APLP interactome. In this review article, we focused on intracellular APP interacting proteins that bind the YENPTY internalization motif located in the last 15 amino acids of the C-terminal region. These proteins, wh...

the main objective of this study is to swing krull intersection theorem in primary decomposition of rings and modules to the primary decomposition of soft rings and soft modules. to fulfill this aim several notions like soft prime ideals, soft maximal ideals, soft primary ideals, and soft radical ideals are introduced for a soft ring over a given unitary commutative ring. consequently, the p...

we define and studyco-noetherian dimension of rings for which the injective envelopeof simple modules have finite krull-dimension. this  is a moritainvariant dimension that measures how far the ring is from beingco-noetherian. the co-noetherian dimension of certain rings,including commutative rings, are determined. it is shown that the class ${mathcal w}_n$ of rings with co-noetherian dimension...

In this paper, we introduce the new notion of strongly J-clean rings associated with polynomial identity g(x) = 0, as a generalization of strongly J-clean rings. We denote strongly J-clean rings associated with polynomial identity g(x) = 0 by strongly g(x)-J-clean rings. Next, we investigate some properties of strongly g(x)-J-clean.

The purpose of this paper is to introduce some new classes of rings and modules that are closely related to the classes of almost Dedekind domains and almost Dedekind modules. We introduce the concepts of $\phi$-almost Dedekind rings and $\Phi$-almost Dedekind modules and study some properties of this classes. In this paper we get some equivalent conditions for $\phi$-almost Dedekind rings and ...

The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate additional roles for APP with an eye towar...

We develop a two-sided market model that captures two unique features of the in-app mobile advertising market: the joint structure of the adverting platform and agency pricing for the app sales channel. In the joint structure of the mobile advertising platform, both the platform owner and the app developer jointly control the provisioning of ads compared to the platform owner alone in the tradi...

Amyloid precursor protein (APP) is a ubiquitously expressed type 1 integral membrane protein. It has the ability to bind numerous extracellular matrix components and propagate signaling responses via its cytoplasmic phospho-tyrosine, (682)YENPTY(687), binding motif. We recently demonstrated increased protein levels of APP, phosphorylated APP (Tyr682), and beta-amyloid (Abeta) in brain vasculatu...

We show that for determinictic polynomial time computation, oracle access to APP, the class of real functions approximable by probabilistic Turing machines, is the same as having oracle access to promise-BPP. First we construct a mapping that maps every function in APP to a promise problem in prBPP, and that maps complete functions to complete promise problems. Then we show an analogue result i...

Amyloid precursor protein (APP) generates the beta-amyloid peptide, postulated to participate in the neurotoxicity of Alzheimer's disease. We report that APP and APLP bind to heme oxygenase (HO), an enzyme whose product, bilirubin, is antioxidant and neuroprotective. The binding of APP inhibits HO activity, and APP with mutations linked to the familial Alzheimer's disease (FAD) provides substan...